Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives
Abstract Objective The prevalence of metabolic syndrome and insulin resistance is twice as high in patients with bipolar disorder compared with the general population, and possibly associated with a disabling illness trajectory of bipolar disorder, an increased risk of cardiovascular disease and pre...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-04-01
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| Series: | International Journal of Bipolar Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40345-019-0142-3 |
| _version_ | 1818989054972133376 |
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| author | Klara Coello Maj Vinberg Filip K. Knop Bente K. Pedersen Roger S. McIntyre Lars V. Kessing Klaus Munkholm |
| author_facet | Klara Coello Maj Vinberg Filip K. Knop Bente K. Pedersen Roger S. McIntyre Lars V. Kessing Klaus Munkholm |
| author_sort | Klara Coello |
| collection | DOAJ |
| description | Abstract Objective The prevalence of metabolic syndrome and insulin resistance is twice as high in patients with bipolar disorder compared with the general population, and possibly associated with a disabling illness trajectory of bipolar disorder, an increased risk of cardiovascular disease and premature death. Despite these detrimental effects, the prevalence of metabolic syndrome and insulin resistance in patients newly diagnosed with bipolar disorder and their unaffected first-degree relatives is largely unknown. Methods In a cross-sectional study of 206 patients with newly diagnosed bipolar disorder, 50 of their unaffected first-degree relatives and 109 healthy age- and sex-matched individuals, we compared the prevalence of metabolic syndrome and insulin resistance (HOMA-IR). In patients with bipolar disorder, we further investigated illness and medication variables associated with the metabolic syndrome and insulin resistance. Results Higher rates of metabolic syndrome (odds ratio = 3.529, 95% CI 1.378–9.041, P = 0.009) and levels of insulin resistance (B = 1.203, 95% CI 1.059–1.367, P = 0.005) were found in patients newly diagnosed with bipolar disorder, but not in their unaffected first-degree relatives compared with matched healthy individuals (data adjusted for sex and age). Most patients with bipolar disorder (94.7%) were diagnosed within the preceding 2 years, and the average illness duration, defined as time from first mood episode, was 10 years. Conclusion Our findings of elevated prevalence of metabolic syndrome and insulin resistance in patients with newly diagnosed bipolar disorder highlight the importance of screening for these conditions at an early stage to employ adequate and early care reducing the risk of cardiovascular disease and premature death. |
| first_indexed | 2024-12-20T19:32:23Z |
| format | Article |
| id | doaj.art-d288830a22e4433582867ff54978d900 |
| institution | Directory Open Access Journal |
| issn | 2194-7511 |
| language | English |
| last_indexed | 2024-12-20T19:32:23Z |
| publishDate | 2019-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Bipolar Disorders |
| spelling | doaj.art-d288830a22e4433582867ff54978d9002022-12-21T19:28:45ZengSpringerOpenInternational Journal of Bipolar Disorders2194-75112019-04-017111310.1186/s40345-019-0142-3Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relativesKlara Coello0Maj Vinberg1Filip K. Knop2Bente K. Pedersen3Roger S. McIntyre4Lars V. Kessing5Klaus Munkholm6Copenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center Copenhagen, Department O, 6243, RigshospitaletCopenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center Copenhagen, Department O, 6243, RigshospitaletDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of CopenhagenMood Disorders Psychopharmacology Unit, University Health NetworkCopenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center Copenhagen, Department O, 6243, RigshospitaletCopenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center Copenhagen, Department O, 6243, RigshospitaletAbstract Objective The prevalence of metabolic syndrome and insulin resistance is twice as high in patients with bipolar disorder compared with the general population, and possibly associated with a disabling illness trajectory of bipolar disorder, an increased risk of cardiovascular disease and premature death. Despite these detrimental effects, the prevalence of metabolic syndrome and insulin resistance in patients newly diagnosed with bipolar disorder and their unaffected first-degree relatives is largely unknown. Methods In a cross-sectional study of 206 patients with newly diagnosed bipolar disorder, 50 of their unaffected first-degree relatives and 109 healthy age- and sex-matched individuals, we compared the prevalence of metabolic syndrome and insulin resistance (HOMA-IR). In patients with bipolar disorder, we further investigated illness and medication variables associated with the metabolic syndrome and insulin resistance. Results Higher rates of metabolic syndrome (odds ratio = 3.529, 95% CI 1.378–9.041, P = 0.009) and levels of insulin resistance (B = 1.203, 95% CI 1.059–1.367, P = 0.005) were found in patients newly diagnosed with bipolar disorder, but not in their unaffected first-degree relatives compared with matched healthy individuals (data adjusted for sex and age). Most patients with bipolar disorder (94.7%) were diagnosed within the preceding 2 years, and the average illness duration, defined as time from first mood episode, was 10 years. Conclusion Our findings of elevated prevalence of metabolic syndrome and insulin resistance in patients with newly diagnosed bipolar disorder highlight the importance of screening for these conditions at an early stage to employ adequate and early care reducing the risk of cardiovascular disease and premature death.http://link.springer.com/article/10.1186/s40345-019-0142-3Bipolar disorderInsulin resistanceMetabolic syndrome XCo-morbidity |
| spellingShingle | Klara Coello Maj Vinberg Filip K. Knop Bente K. Pedersen Roger S. McIntyre Lars V. Kessing Klaus Munkholm Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives International Journal of Bipolar Disorders Bipolar disorder Insulin resistance Metabolic syndrome X Co-morbidity |
| title | Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives |
| title_full | Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives |
| title_fullStr | Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives |
| title_full_unstemmed | Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives |
| title_short | Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives |
| title_sort | metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first degree relatives |
| topic | Bipolar disorder Insulin resistance Metabolic syndrome X Co-morbidity |
| url | http://link.springer.com/article/10.1186/s40345-019-0142-3 |
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