Fish Scale Gelatin Nanofibers with <i>Helichrysum italicum</i> and Lavandula latifolia Essential Oils for Bioactive Wound-Healing Dressings
Essential oils are valuable alternatives to synthetic antibiotics that have the potential to avoid the pathogen resistance side effects generated by leather. <i>Helichrysum italicum</i> and Lavandula latifolia essential oils combined with fish scale gelatin were electrospun using a coaxi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/12/2692 |
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| author | Carmen Gaidau Maria Râpă Maria Stanca Mariana-Luiza Tanase Laura Olariu Rodica Roxana Constantinescu Andrada Lazea-Stoyanova Cosmin-Andrei Alexe Madalina Tudorache |
| author_facet | Carmen Gaidau Maria Râpă Maria Stanca Mariana-Luiza Tanase Laura Olariu Rodica Roxana Constantinescu Andrada Lazea-Stoyanova Cosmin-Andrei Alexe Madalina Tudorache |
| author_sort | Carmen Gaidau |
| collection | DOAJ |
| description | Essential oils are valuable alternatives to synthetic antibiotics that have the potential to avoid the pathogen resistance side effects generated by leather. <i>Helichrysum italicum</i> and Lavandula latifolia essential oils combined with fish scale gelatin were electrospun using a coaxial technique to design new bioactive materials for skin wound dressings fabrication. Fish scale gelatins were extracted from carp fish scales using two variants of the same method, with and without ethylenediaminetetraacetic acid (EDTA). Both variants showed very good electrospinning properties when dissolved in acetic acid solvent. Fish scale gelatin nanofibers with <i>Helichrysum italicum</i> and Lavandula latifolia essential oil emulsions ensured low microbial load (under 100 CFU/g of total number of aerobic microorganisms and total number of yeasts and filamentous fungi) and the absence of <i>Staphylococcus aureus</i> ATCC 6538, <i>Escherichia coli</i> ATCC 10536, and <i>Candida albicans</i> ATCC 1023 as compared to fish scale gelatin without essential oils, which recommends them for pharmaceutical or topical applications. A scratch-test performed on human dermal fibroblasts proved that the biomaterials contributing to the wound healing process included fish scale gelatin nanofibers without EDTA (0.5% and 1%), fish scale gelatin nanofibers without EDTA and <i>Lavandula latifolia</i> essential oil emulsion (1%), fish scale gelatin nanofibers with EDTA (0.6%), and fish scale gelatin nanofibers with EDTA with <i>Helichrysum italicum</i> essential oil emulsion (1% and 2%). |
| first_indexed | 2024-03-08T20:27:27Z |
| format | Article |
| id | doaj.art-d288d6442f524cc3a46c2b17bf61f60a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-08T20:27:27Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d288d6442f524cc3a46c2b17bf61f60a2023-12-22T14:32:00ZengMDPI AGPharmaceutics1999-49232023-11-011512269210.3390/pharmaceutics15122692Fish Scale Gelatin Nanofibers with <i>Helichrysum italicum</i> and Lavandula latifolia Essential Oils for Bioactive Wound-Healing DressingsCarmen Gaidau0Maria Râpă1Maria Stanca2Mariana-Luiza Tanase3Laura Olariu4Rodica Roxana Constantinescu5Andrada Lazea-Stoyanova6Cosmin-Andrei Alexe7Madalina Tudorache8The National Research & Development Institute for Textiles and Leather, Division Leather and Footwear Research Institute, 31251 Bucharest, RomaniaFaculty of Materials Science and Engineering, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, RomaniaThe National Research & Development Institute for Textiles and Leather, Division Leather and Footwear Research Institute, 31251 Bucharest, RomaniaSC Biotehnos SA, 3-5 Gorunului Street, 075100 Otopeni, RomaniaSC Biotehnos SA, 3-5 Gorunului Street, 075100 Otopeni, RomaniaThe National Research & Development Institute for Textiles and Leather, Division Leather and Footwear Research Institute, 31251 Bucharest, RomaniaNational Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, RomaniaThe National Research & Development Institute for Textiles and Leather, Division Leather and Footwear Research Institute, 31251 Bucharest, RomaniaLaboratory for Quality Control and Process Monitoring, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta Boulevard, 030018 Bucharest, RomaniaEssential oils are valuable alternatives to synthetic antibiotics that have the potential to avoid the pathogen resistance side effects generated by leather. <i>Helichrysum italicum</i> and Lavandula latifolia essential oils combined with fish scale gelatin were electrospun using a coaxial technique to design new bioactive materials for skin wound dressings fabrication. Fish scale gelatins were extracted from carp fish scales using two variants of the same method, with and without ethylenediaminetetraacetic acid (EDTA). Both variants showed very good electrospinning properties when dissolved in acetic acid solvent. Fish scale gelatin nanofibers with <i>Helichrysum italicum</i> and Lavandula latifolia essential oil emulsions ensured low microbial load (under 100 CFU/g of total number of aerobic microorganisms and total number of yeasts and filamentous fungi) and the absence of <i>Staphylococcus aureus</i> ATCC 6538, <i>Escherichia coli</i> ATCC 10536, and <i>Candida albicans</i> ATCC 1023 as compared to fish scale gelatin without essential oils, which recommends them for pharmaceutical or topical applications. A scratch-test performed on human dermal fibroblasts proved that the biomaterials contributing to the wound healing process included fish scale gelatin nanofibers without EDTA (0.5% and 1%), fish scale gelatin nanofibers without EDTA and <i>Lavandula latifolia</i> essential oil emulsion (1%), fish scale gelatin nanofibers with EDTA (0.6%), and fish scale gelatin nanofibers with EDTA with <i>Helichrysum italicum</i> essential oil emulsion (1% and 2%).https://www.mdpi.com/1999-4923/15/12/2692essential oilsfish scale gelatinsnanofiberselectrospinningwound healing |
| spellingShingle | Carmen Gaidau Maria Râpă Maria Stanca Mariana-Luiza Tanase Laura Olariu Rodica Roxana Constantinescu Andrada Lazea-Stoyanova Cosmin-Andrei Alexe Madalina Tudorache Fish Scale Gelatin Nanofibers with <i>Helichrysum italicum</i> and Lavandula latifolia Essential Oils for Bioactive Wound-Healing Dressings Pharmaceutics essential oils fish scale gelatins nanofibers electrospinning wound healing |
| title | Fish Scale Gelatin Nanofibers with <i>Helichrysum italicum</i> and Lavandula latifolia Essential Oils for Bioactive Wound-Healing Dressings |
| title_full | Fish Scale Gelatin Nanofibers with <i>Helichrysum italicum</i> and Lavandula latifolia Essential Oils for Bioactive Wound-Healing Dressings |
| title_fullStr | Fish Scale Gelatin Nanofibers with <i>Helichrysum italicum</i> and Lavandula latifolia Essential Oils for Bioactive Wound-Healing Dressings |
| title_full_unstemmed | Fish Scale Gelatin Nanofibers with <i>Helichrysum italicum</i> and Lavandula latifolia Essential Oils for Bioactive Wound-Healing Dressings |
| title_short | Fish Scale Gelatin Nanofibers with <i>Helichrysum italicum</i> and Lavandula latifolia Essential Oils for Bioactive Wound-Healing Dressings |
| title_sort | fish scale gelatin nanofibers with i helichrysum italicum i and lavandula latifolia essential oils for bioactive wound healing dressings |
| topic | essential oils fish scale gelatins nanofibers electrospinning wound healing |
| url | https://www.mdpi.com/1999-4923/15/12/2692 |
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