Research progress of m6A methylation modification in ocular diseases
N6-methyladenosine(m6A), the most common, abundant, and conserved RNA modification in eukaryotic cells, regulates RNA splicing, stability, output, degradation and translation through m6A methyltransferase, m6A demethylase, and m6A methylated binding proteins. Recent studies have found that abnormal...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2024-04-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2024/4/202404018.pdf |
| _version_ | 1797249386505306112 |
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| author | Xue Yuyu Liu Chunmeng Chen Jie Ye Hejiang |
| author_facet | Xue Yuyu Liu Chunmeng Chen Jie Ye Hejiang |
| author_sort | Xue Yuyu |
| collection | DOAJ |
| description | N6-methyladenosine(m6A), the most common, abundant, and conserved RNA modification in eukaryotic cells, regulates RNA splicing, stability, output, degradation and translation through m6A methyltransferase, m6A demethylase, and m6A methylated binding proteins. Recent studies have found that abnormal m6A methylation may mediate a variety of pathological processes in eyes and participate in the occurrence and development of metabolic, inflammatory, degenerative ocular diseases and ocular tumors, such as diabetic retinopathy, cataract, age-related macular degeneration and uveal melanoma. This review aims to summarize the roles of m6A methylation modification in ocular cells and ocular diseases, elucidate the potential molecular mechanisms of m6A methylation in ocular diseases, so as to encourage innovative approaches in the treatment of these ocular diseases. |
| first_indexed | 2024-04-24T20:29:40Z |
| format | Article |
| id | doaj.art-d289a65b41d641e48d60ec9b81080cbe |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-24T20:29:40Z |
| publishDate | 2024-04-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-d289a65b41d641e48d60ec9b81080cbe2024-03-22T03:14:27ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232024-04-0124458959510.3980/j.issn.1672-5123.2024.4.18202404018Research progress of m6A methylation modification in ocular diseasesXue Yuyu0Liu Chunmeng1Chen Jie2Ye Hejiang3Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China; Department of Ophthalmology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, ChinaChengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China; Department of Ophthalmology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, ChinaDepartment of Ophthalmology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, ChinaDepartment of Ophthalmology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, ChinaN6-methyladenosine(m6A), the most common, abundant, and conserved RNA modification in eukaryotic cells, regulates RNA splicing, stability, output, degradation and translation through m6A methyltransferase, m6A demethylase, and m6A methylated binding proteins. Recent studies have found that abnormal m6A methylation may mediate a variety of pathological processes in eyes and participate in the occurrence and development of metabolic, inflammatory, degenerative ocular diseases and ocular tumors, such as diabetic retinopathy, cataract, age-related macular degeneration and uveal melanoma. This review aims to summarize the roles of m6A methylation modification in ocular cells and ocular diseases, elucidate the potential molecular mechanisms of m6A methylation in ocular diseases, so as to encourage innovative approaches in the treatment of these ocular diseases.http://ies.ijo.cn/cn_publish/2024/4/202404018.pdfn6-methyladenosine(m6a)rna methylationdiabetic retinopathycataractage-related macular degenerationuveal melanoma |
| spellingShingle | Xue Yuyu Liu Chunmeng Chen Jie Ye Hejiang Research progress of m6A methylation modification in ocular diseases Guoji Yanke Zazhi n6-methyladenosine(m6a) rna methylation diabetic retinopathy cataract age-related macular degeneration uveal melanoma |
| title | Research progress of m6A methylation modification in ocular diseases |
| title_full | Research progress of m6A methylation modification in ocular diseases |
| title_fullStr | Research progress of m6A methylation modification in ocular diseases |
| title_full_unstemmed | Research progress of m6A methylation modification in ocular diseases |
| title_short | Research progress of m6A methylation modification in ocular diseases |
| title_sort | research progress of m6a methylation modification in ocular diseases |
| topic | n6-methyladenosine(m6a) rna methylation diabetic retinopathy cataract age-related macular degeneration uveal melanoma |
| url | http://ies.ijo.cn/cn_publish/2024/4/202404018.pdf |
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