Self-referential Processing in Remitted Depression: An Event-Related Potential Study
Background: Identifying mechanisms of major depressive disorder that continue into remission is critical, as these mechanisms may contribute to subsequent depressive episodes. Biobehavioral markers related to depressogenic self-referential processing biases have been identified in adults with depres...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Biological Psychiatry Global Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667174321001750 |
| _version_ | 1797948274930352128 |
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| author | Grace O. Allison Rahil A. Kamath Vivian Carrillo Kira L. Alqueza David Pagliaccio George M. Slavich Stewart A. Shankman Randy P. Auerbach |
| author_facet | Grace O. Allison Rahil A. Kamath Vivian Carrillo Kira L. Alqueza David Pagliaccio George M. Slavich Stewart A. Shankman Randy P. Auerbach |
| author_sort | Grace O. Allison |
| collection | DOAJ |
| description | Background: Identifying mechanisms of major depressive disorder that continue into remission is critical, as these mechanisms may contribute to subsequent depressive episodes. Biobehavioral markers related to depressogenic self-referential processing biases have been identified in adults with depression. Thus, we investigated whether these risk factors persisted during remission as well as contributed to the occurrence of stress and depressive symptoms over time. Methods: At baseline, adults with remitted depression (n = 33) and healthy control subjects (n = 33) were administered diagnostic and stress interviews as well as self-report symptom measures. In addition, participants completed a self-referential encoding task while electroencephalography data were acquired. Stress interviews and self-report symptom measures were readministered at the 6-month follow-up assessment. Results: Drift diffusion modeling showed that compared with healthy individuals, adults with remitted depression exhibited a slower drift rate to negative stimuli, indicating a slower tendency to reject negative stimuli as self-relevant. At the 6-month follow-up assessment, a slower drift rate to negative stimuli predicted greater interpersonal stress severity among individuals with remitted depression but not healthy individuals while controlling for both baseline depression symptoms and interpersonal stress severity. Highlighting the specificity of this effect, results were nonsignificant when predicting noninterpersonal stress. For self-relevant positive words endorsed, adults with remitted depression exhibited smaller left- than right-hemisphere late positive potential amplitudes; healthy control subjects did not show hemispheric differences. Conclusions: Self-referential processing deficits persist into remission. In line with the stress generation framework, these biases predicted the occurrence of interpersonal stress, which may provide insight about a potential pathway for the re-emergence of depressive symptoms. |
| first_indexed | 2024-04-10T21:40:44Z |
| format | Article |
| id | doaj.art-d28a51984cfa4750ba7a33ecc3dbc2c8 |
| institution | Directory Open Access Journal |
| issn | 2667-1743 |
| language | English |
| last_indexed | 2024-04-10T21:40:44Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj.art-d28a51984cfa4750ba7a33ecc3dbc2c82023-01-19T04:17:58ZengElsevierBiological Psychiatry Global Open Science2667-17432023-01-0131119129Self-referential Processing in Remitted Depression: An Event-Related Potential StudyGrace O. Allison0Rahil A. Kamath1Vivian Carrillo2Kira L. Alqueza3David Pagliaccio4George M. Slavich5Stewart A. Shankman6Randy P. Auerbach7Department of Psychiatry, Columbia University, New York, New YorkDepartment of Psychiatry, Columbia University, New York, New YorkDepartment of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IllinoisDepartment of Psychiatry, Columbia University, New York, New YorkDepartment of Psychiatry, Columbia University, New York, New YorkCousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CaliforniaDepartment of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IllinoisDepartment of Psychiatry, Columbia University, New York, New York; Division of Clinical Developmental Neuroscience, Sackler Institute, New York, New York; Address correspondence to Randy P. Auerbach, Ph.D.Background: Identifying mechanisms of major depressive disorder that continue into remission is critical, as these mechanisms may contribute to subsequent depressive episodes. Biobehavioral markers related to depressogenic self-referential processing biases have been identified in adults with depression. Thus, we investigated whether these risk factors persisted during remission as well as contributed to the occurrence of stress and depressive symptoms over time. Methods: At baseline, adults with remitted depression (n = 33) and healthy control subjects (n = 33) were administered diagnostic and stress interviews as well as self-report symptom measures. In addition, participants completed a self-referential encoding task while electroencephalography data were acquired. Stress interviews and self-report symptom measures were readministered at the 6-month follow-up assessment. Results: Drift diffusion modeling showed that compared with healthy individuals, adults with remitted depression exhibited a slower drift rate to negative stimuli, indicating a slower tendency to reject negative stimuli as self-relevant. At the 6-month follow-up assessment, a slower drift rate to negative stimuli predicted greater interpersonal stress severity among individuals with remitted depression but not healthy individuals while controlling for both baseline depression symptoms and interpersonal stress severity. Highlighting the specificity of this effect, results were nonsignificant when predicting noninterpersonal stress. For self-relevant positive words endorsed, adults with remitted depression exhibited smaller left- than right-hemisphere late positive potential amplitudes; healthy control subjects did not show hemispheric differences. Conclusions: Self-referential processing deficits persist into remission. In line with the stress generation framework, these biases predicted the occurrence of interpersonal stress, which may provide insight about a potential pathway for the re-emergence of depressive symptoms.http://www.sciencedirect.com/science/article/pii/S2667174321001750Cognitive vulnerabilityLate positive potentialMajor depressive disorderRemissionStress generation |
| spellingShingle | Grace O. Allison Rahil A. Kamath Vivian Carrillo Kira L. Alqueza David Pagliaccio George M. Slavich Stewart A. Shankman Randy P. Auerbach Self-referential Processing in Remitted Depression: An Event-Related Potential Study Biological Psychiatry Global Open Science Cognitive vulnerability Late positive potential Major depressive disorder Remission Stress generation |
| title | Self-referential Processing in Remitted Depression: An Event-Related Potential Study |
| title_full | Self-referential Processing in Remitted Depression: An Event-Related Potential Study |
| title_fullStr | Self-referential Processing in Remitted Depression: An Event-Related Potential Study |
| title_full_unstemmed | Self-referential Processing in Remitted Depression: An Event-Related Potential Study |
| title_short | Self-referential Processing in Remitted Depression: An Event-Related Potential Study |
| title_sort | self referential processing in remitted depression an event related potential study |
| topic | Cognitive vulnerability Late positive potential Major depressive disorder Remission Stress generation |
| url | http://www.sciencedirect.com/science/article/pii/S2667174321001750 |
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