Haemato-biochemical alterations induced by Diclofenac sodium toxicity in Swiss albino mice
Aim: An experiment was conducted to study the haemato-biochemical alterations induced by Diclofenac Sodium toxicity. Materials and Methods: 48 Swiss albino mice of either sex, divided uniformly into four different groups. The mice of group I received only deionised water as control while, group II,...
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| Format: | Article |
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Veterinary World
2012-01-01
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| Series: | Veterinary World |
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| Online Access: | http://www.scopemed.org/fulltextpdf.php?mno=20078 |
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| author | Dineshbhai J. Ghodasara Jatin H. Patel Ketan B. Thakor B. M. Jivani Kantibhai S. Prajapati Dhaval T. Fefar Basavraj S. Thanagari Bholanath P. Joshi Vishal V. Undhad |
| author_facet | Dineshbhai J. Ghodasara Jatin H. Patel Ketan B. Thakor B. M. Jivani Kantibhai S. Prajapati Dhaval T. Fefar Basavraj S. Thanagari Bholanath P. Joshi Vishal V. Undhad |
| author_sort | Dineshbhai J. Ghodasara |
| collection | DOAJ |
| description | Aim: An experiment was conducted to study the haemato-biochemical alterations induced by Diclofenac Sodium toxicity. Materials and Methods: 48 Swiss albino mice of either sex, divided uniformly into four different groups. The mice of group I received only deionised water as control while, group II, III and IV were given Diclofenac sodium @ 2.37 mg/kg B.W, 4.75 mg/kg B.W, 9.5 mg/kg B.W orally for 28 days. Results: In dose dependant significant reductions in TEC, Hb, PCV, MCV, MCHC were observed. No significant change was observed in total WBC count in both the sexes. However, relative values of leukocytes indicated relative neutrophilia and relative lymphopenia in higher group. Biochemically dose dependant significant changes were observed for AST, ALT, Total bilirubin, Total protein, Albumin, Globulin, Cholesterol, Urea, Creatinine and Uric acid in male and female animals. Conclusion: The present study indicates hepatobilliary, nephric and gastrointestinal toxicity in albino swiss mice due to Diclofenac Sodium Toxicity. [Vet. World 2012; 5(7.000): 417-419] |
| first_indexed | 2024-12-17T03:17:30Z |
| format | Article |
| id | doaj.art-d28b8616b3ba451f98ae3a0455ede90a |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-12-17T03:17:30Z |
| publishDate | 2012-01-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-d28b8616b3ba451f98ae3a0455ede90a2022-12-21T22:05:36ZengVeterinary WorldVeterinary World0972-89882231-09162012-01-0157.000417419Haemato-biochemical alterations induced by Diclofenac sodium toxicity in Swiss albino miceDineshbhai J. GhodasaraJatin H. PatelKetan B. ThakorB. M. JivaniKantibhai S. PrajapatiDhaval T. FefarBasavraj S. ThanagariBholanath P. JoshiVishal V. UndhadAim: An experiment was conducted to study the haemato-biochemical alterations induced by Diclofenac Sodium toxicity. Materials and Methods: 48 Swiss albino mice of either sex, divided uniformly into four different groups. The mice of group I received only deionised water as control while, group II, III and IV were given Diclofenac sodium @ 2.37 mg/kg B.W, 4.75 mg/kg B.W, 9.5 mg/kg B.W orally for 28 days. Results: In dose dependant significant reductions in TEC, Hb, PCV, MCV, MCHC were observed. No significant change was observed in total WBC count in both the sexes. However, relative values of leukocytes indicated relative neutrophilia and relative lymphopenia in higher group. Biochemically dose dependant significant changes were observed for AST, ALT, Total bilirubin, Total protein, Albumin, Globulin, Cholesterol, Urea, Creatinine and Uric acid in male and female animals. Conclusion: The present study indicates hepatobilliary, nephric and gastrointestinal toxicity in albino swiss mice due to Diclofenac Sodium Toxicity. [Vet. World 2012; 5(7.000): 417-419]http://www.scopemed.org/fulltextpdf.php?mno=20078BiochemicalHaematologyDiclofenac sodiumMice |
| spellingShingle | Dineshbhai J. Ghodasara Jatin H. Patel Ketan B. Thakor B. M. Jivani Kantibhai S. Prajapati Dhaval T. Fefar Basavraj S. Thanagari Bholanath P. Joshi Vishal V. Undhad Haemato-biochemical alterations induced by Diclofenac sodium toxicity in Swiss albino mice Veterinary World Biochemical Haematology Diclofenac sodium Mice |
| title | Haemato-biochemical alterations induced by Diclofenac sodium toxicity in Swiss albino mice |
| title_full | Haemato-biochemical alterations induced by Diclofenac sodium toxicity in Swiss albino mice |
| title_fullStr | Haemato-biochemical alterations induced by Diclofenac sodium toxicity in Swiss albino mice |
| title_full_unstemmed | Haemato-biochemical alterations induced by Diclofenac sodium toxicity in Swiss albino mice |
| title_short | Haemato-biochemical alterations induced by Diclofenac sodium toxicity in Swiss albino mice |
| title_sort | haemato biochemical alterations induced by diclofenac sodium toxicity in swiss albino mice |
| topic | Biochemical Haematology Diclofenac sodium Mice |
| url | http://www.scopemed.org/fulltextpdf.php?mno=20078 |
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