Shotgun sequencing of sonication fluid for the diagnosis of orthopaedic implant-associated infections with Cutibacterium acnes as suspected causative agent

Shotgun sequencing of sonication fluid for the diagnosis of orthopaedic implant-associated infections with Cutibacterium acnes as suspected causative agent

Orthopaedic implant-associated infections (OIAIs) due to Cutibacterium acnes can be difficult to diagnose. The aim of this pilot study was to determine if metagenomic next-generation sequencing (mNGS) can provide additional information to improve the diagnosis of C. acnes OIAIs. mNGS was performed o...

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Bibliographic Details
Main Authors: Diana Salomi Ponraj, Michael Lund, Jeppe Lange, Anja Poehlein, Axel Himmelbach, Thomas Falstie-Jensen, Nis Pedersen Jørgensen, Christen Ravn, Holger Brüggemann
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Cutibacterium acnes
shotgun sequencing
metagenomics
orthopaedic implant-associated infections
prosthetic infections
sonication fluid
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1165017/full

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