Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs

Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs

Fracture healing is highly dependent on an early inflammatory response in which prostaglandin production by cyclo-oxygenases (COX) plays a crucial role. Current patient analgesia regimens favor opioids over Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) since the latter have been implicated in delay...

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Bibliographic Details
Main Authors: L. Henry Goodnough, Thomas H. Ambrosi, Holly M. Steininger, M. Gohazrua K. Butler, Malachia Y. Hoover, HyeRan Choo, Noelle L. Van Rysselberghe, Michael J. Bellino, Julius A. Bishop, Michael J. Gardner, Charles K. F. Chan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Endocrinology
Subjects:
skeletal stem cells (SSCs)
non-steroid antiinflamatory drugs
species specificity
bone regeneration
inflammation
fracture healing
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.924927/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.924927/full

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