ABO Blood Groups as a Disease Marker to Predict Atrial Fibrillation Recurrence after Catheter Ablation
Chronic inflammation harbors a vulnerable substrate for atrial fibrillation (AF) recurrence after catheter ablation. However, whether the ABO blood types are associated with AF recurrence after catheter ablation is unknown. A total of 2106 AF patients (1552 men, 554 women) who underwent catheter abl...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/2/355 |
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| author | Shin-Huei Liu Chheng Chhay Yu-Feng Hu Yenn-Jiang Lin Shih-Lin Chang Li-Wei Lo Fa-Po Chung Ta-Chuan Tuan Tze-Fan Chao Jo-Nan Liao Chin-Yu Lin Ting-Yung Chang Ling Kuo Chih-Min Liu An Nu-Khanh Ton Dony Yugo Shih-Ann Chen |
| author_facet | Shin-Huei Liu Chheng Chhay Yu-Feng Hu Yenn-Jiang Lin Shih-Lin Chang Li-Wei Lo Fa-Po Chung Ta-Chuan Tuan Tze-Fan Chao Jo-Nan Liao Chin-Yu Lin Ting-Yung Chang Ling Kuo Chih-Min Liu An Nu-Khanh Ton Dony Yugo Shih-Ann Chen |
| author_sort | Shin-Huei Liu |
| collection | DOAJ |
| description | Chronic inflammation harbors a vulnerable substrate for atrial fibrillation (AF) recurrence after catheter ablation. However, whether the ABO blood types are associated with AF recurrence after catheter ablation is unknown. A total of 2106 AF patients (1552 men, 554 women) who underwent catheter ablation were enrolled retrospectively. The patients were separated into two groups according to the ABO blood types, the O-type (n = 910, 43.21%) and the non-O-type groups (A, B, or AB type) (n = 1196, 56.79%). The clinical characteristics, AF recurrence, and risk predictors were investigated. The non-O type blood group had a higher incidence of diabetes mellitus (11.90 vs. 9.03%, <i>p</i> = 0.035), larger left atrial diameters (39.43 ± 6.74 vs. 38.20 ± 6.47, <i>p</i> = 0.007), and decreased left ventricular ejection fractions (56.01 ± 7.33 vs. 58.65 ± 6.34, <i>p</i> = 0.044) than the O-type blood group. In the non-paroxysmal AF (non-PAF) patients, the non-O-type blood groups have significantly higher incidences of very late recurrence (67.46 vs. 32.54%, <i>p</i> = 0.045) than those in the O-type blood group. The multivariate analysis revealed the non-O blood group (odd ratio 1.40, <i>p</i> = 0.022) and amiodarone (odd ratio 1.44, <i>p</i> = 0.013) were independent predictors for very late recurrence in the non-PAF patients after catheter ablation, which could be applied as a useful disease marker. This work highlighted the potential link between the ABO blood types and inflammatory activities that contribute to the pathogenic development of AF. The presence of surface antigens on cardiomyocytes or blood cells in patients with different ABO blood types will have an impactful role in risk stratification for AF prognosis after catheter ablation. Further prospective studies are warranted to prove the translational benefits of the ABO blood types for the patients receiving catheter ablation. |
| first_indexed | 2024-03-11T08:35:04Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-11T08:35:04Z |
| publishDate | 2023-02-01 |
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| spelling | doaj.art-d29144aba8914951bdf02f686f0407552023-11-16T21:34:17ZengMDPI AGJournal of Personalized Medicine2075-44262023-02-0113235510.3390/jpm13020355ABO Blood Groups as a Disease Marker to Predict Atrial Fibrillation Recurrence after Catheter AblationShin-Huei Liu0Chheng Chhay1Yu-Feng Hu2Yenn-Jiang Lin3Shih-Lin Chang4Li-Wei Lo5Fa-Po Chung6Ta-Chuan Tuan7Tze-Fan Chao8Jo-Nan Liao9Chin-Yu Lin10Ting-Yung Chang11Ling Kuo12Chih-Min Liu13An Nu-Khanh Ton14Dony Yugo15Shih-Ann Chen16Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanHeart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, TaiwanChronic inflammation harbors a vulnerable substrate for atrial fibrillation (AF) recurrence after catheter ablation. However, whether the ABO blood types are associated with AF recurrence after catheter ablation is unknown. A total of 2106 AF patients (1552 men, 554 women) who underwent catheter ablation were enrolled retrospectively. The patients were separated into two groups according to the ABO blood types, the O-type (n = 910, 43.21%) and the non-O-type groups (A, B, or AB type) (n = 1196, 56.79%). The clinical characteristics, AF recurrence, and risk predictors were investigated. The non-O type blood group had a higher incidence of diabetes mellitus (11.90 vs. 9.03%, <i>p</i> = 0.035), larger left atrial diameters (39.43 ± 6.74 vs. 38.20 ± 6.47, <i>p</i> = 0.007), and decreased left ventricular ejection fractions (56.01 ± 7.33 vs. 58.65 ± 6.34, <i>p</i> = 0.044) than the O-type blood group. In the non-paroxysmal AF (non-PAF) patients, the non-O-type blood groups have significantly higher incidences of very late recurrence (67.46 vs. 32.54%, <i>p</i> = 0.045) than those in the O-type blood group. The multivariate analysis revealed the non-O blood group (odd ratio 1.40, <i>p</i> = 0.022) and amiodarone (odd ratio 1.44, <i>p</i> = 0.013) were independent predictors for very late recurrence in the non-PAF patients after catheter ablation, which could be applied as a useful disease marker. This work highlighted the potential link between the ABO blood types and inflammatory activities that contribute to the pathogenic development of AF. The presence of surface antigens on cardiomyocytes or blood cells in patients with different ABO blood types will have an impactful role in risk stratification for AF prognosis after catheter ablation. Further prospective studies are warranted to prove the translational benefits of the ABO blood types for the patients receiving catheter ablation.https://www.mdpi.com/2075-4426/13/2/355ABO blood groupatrial fibrillationlate recurrencevery late recurrencebiomarker |
| spellingShingle | Shin-Huei Liu Chheng Chhay Yu-Feng Hu Yenn-Jiang Lin Shih-Lin Chang Li-Wei Lo Fa-Po Chung Ta-Chuan Tuan Tze-Fan Chao Jo-Nan Liao Chin-Yu Lin Ting-Yung Chang Ling Kuo Chih-Min Liu An Nu-Khanh Ton Dony Yugo Shih-Ann Chen ABO Blood Groups as a Disease Marker to Predict Atrial Fibrillation Recurrence after Catheter Ablation Journal of Personalized Medicine ABO blood group atrial fibrillation late recurrence very late recurrence biomarker |
| title | ABO Blood Groups as a Disease Marker to Predict Atrial Fibrillation Recurrence after Catheter Ablation |
| title_full | ABO Blood Groups as a Disease Marker to Predict Atrial Fibrillation Recurrence after Catheter Ablation |
| title_fullStr | ABO Blood Groups as a Disease Marker to Predict Atrial Fibrillation Recurrence after Catheter Ablation |
| title_full_unstemmed | ABO Blood Groups as a Disease Marker to Predict Atrial Fibrillation Recurrence after Catheter Ablation |
| title_short | ABO Blood Groups as a Disease Marker to Predict Atrial Fibrillation Recurrence after Catheter Ablation |
| title_sort | abo blood groups as a disease marker to predict atrial fibrillation recurrence after catheter ablation |
| topic | ABO blood group atrial fibrillation late recurrence very late recurrence biomarker |
| url | https://www.mdpi.com/2075-4426/13/2/355 |
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