Plant Nanovesicles for Essential Oil Delivery
Essential oils’ therapeutic potential is highly recognized, with many applications rising due to reported anti-inflammatory, cardioprotective, neuroprotective, anti-aging, and anti-cancer effects. Nevertheless, clinical translation still remains a challenge, mainly due to essential oils’ volatility...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/12/2581 |
| _version_ | 1797455790125088768 |
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| author | Mónica Zuzarte Carla Vitorino Lígia Salgueiro Henrique Girão |
| author_facet | Mónica Zuzarte Carla Vitorino Lígia Salgueiro Henrique Girão |
| author_sort | Mónica Zuzarte |
| collection | DOAJ |
| description | Essential oils’ therapeutic potential is highly recognized, with many applications rising due to reported anti-inflammatory, cardioprotective, neuroprotective, anti-aging, and anti-cancer effects. Nevertheless, clinical translation still remains a challenge, mainly due to essential oils’ volatility and low water solubility and stability. The present review gathers relevant information and postulates on the potential application of plant nanovesicles to effectively deliver essential oils to target organs. Indeed, plant nanovesicles are emerging as alternatives to mammalian vesicles and synthetic carriers due to their safety, stability, non-toxicity, and low immunogenicity. Moreover, they can be produced on a large scale from various plant parts, enabling an easier, more rapid, and less costly industrial application that could add value to waste products and boost the circular economy. Importantly, the use of plant nanovesicles as delivery platforms could increase essential oils’ bioavailability and improve chemical stability while reducing volatility and toxicity issues. Additionally, using targeting strategies, essential oils’ selectivity, drug delivery, and efficacy could be improved, ultimately leading to dose reduction and patient compliance. Bearing this in mind, information on current pharmaceutical technologies available to enable distinct routes of administration of loaded vesicles is also discussed. |
| first_indexed | 2024-03-09T15:58:45Z |
| format | Article |
| id | doaj.art-d2923cfe6d344c8e85525a40ec58262c |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:45Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d2923cfe6d344c8e85525a40ec58262c2023-11-24T17:18:25ZengMDPI AGPharmaceutics1999-49232022-11-011412258110.3390/pharmaceutics14122581Plant Nanovesicles for Essential Oil DeliveryMónica Zuzarte0Carla Vitorino1Lígia Salgueiro2Henrique Girão3Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3004-548 Coimbra, PortugalFaculty of Pharmacy, University of Coimbra, 3004-548 Coimbra, PortugalFaculty of Pharmacy, University of Coimbra, 3004-548 Coimbra, PortugalCoimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3004-548 Coimbra, PortugalEssential oils’ therapeutic potential is highly recognized, with many applications rising due to reported anti-inflammatory, cardioprotective, neuroprotective, anti-aging, and anti-cancer effects. Nevertheless, clinical translation still remains a challenge, mainly due to essential oils’ volatility and low water solubility and stability. The present review gathers relevant information and postulates on the potential application of plant nanovesicles to effectively deliver essential oils to target organs. Indeed, plant nanovesicles are emerging as alternatives to mammalian vesicles and synthetic carriers due to their safety, stability, non-toxicity, and low immunogenicity. Moreover, they can be produced on a large scale from various plant parts, enabling an easier, more rapid, and less costly industrial application that could add value to waste products and boost the circular economy. Importantly, the use of plant nanovesicles as delivery platforms could increase essential oils’ bioavailability and improve chemical stability while reducing volatility and toxicity issues. Additionally, using targeting strategies, essential oils’ selectivity, drug delivery, and efficacy could be improved, ultimately leading to dose reduction and patient compliance. Bearing this in mind, information on current pharmaceutical technologies available to enable distinct routes of administration of loaded vesicles is also discussed.https://www.mdpi.com/1999-4923/14/12/2581volatile compoundsplant-derived vesiclesextracellular vesiclesfunctionalized vesicles |
| spellingShingle | Mónica Zuzarte Carla Vitorino Lígia Salgueiro Henrique Girão Plant Nanovesicles for Essential Oil Delivery Pharmaceutics volatile compounds plant-derived vesicles extracellular vesicles functionalized vesicles |
| title | Plant Nanovesicles for Essential Oil Delivery |
| title_full | Plant Nanovesicles for Essential Oil Delivery |
| title_fullStr | Plant Nanovesicles for Essential Oil Delivery |
| title_full_unstemmed | Plant Nanovesicles for Essential Oil Delivery |
| title_short | Plant Nanovesicles for Essential Oil Delivery |
| title_sort | plant nanovesicles for essential oil delivery |
| topic | volatile compounds plant-derived vesicles extracellular vesicles functionalized vesicles |
| url | https://www.mdpi.com/1999-4923/14/12/2581 |
| work_keys_str_mv | AT monicazuzarte plantnanovesiclesforessentialoildelivery AT carlavitorino plantnanovesiclesforessentialoildelivery AT ligiasalgueiro plantnanovesiclesforessentialoildelivery AT henriquegirao plantnanovesiclesforessentialoildelivery |