Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?
The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix...
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MDPI AG
2021-11-01
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| Series: | Pharmaceuticals |
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| author | Madhan Jeyaraman Sathish Muthu Prakash Gangadaran Rajni Ranjan Naveen Jeyaraman Gollahalli Shivashankar Prajwal Prabhu Chandra Mishra Ramya Lakshmi Rajendran Byeong-Cheol Ahn |
| author_facet | Madhan Jeyaraman Sathish Muthu Prakash Gangadaran Rajni Ranjan Naveen Jeyaraman Gollahalli Shivashankar Prajwal Prabhu Chandra Mishra Ramya Lakshmi Rajendran Byeong-Cheol Ahn |
| author_sort | Madhan Jeyaraman |
| collection | DOAJ |
| description | The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix environment. Their role in union and remodeling of fracture is well known. However, the periosteum as a source of mesenchymal stem cells has not been explored in detail. Moreover, with the continuous expansion of techniques, newer insights have been acquired into the roles and regulation of these periosteal cells. From a therapeutic standpoint, the periosteum as a source of tissue engineering has gained much attraction. Apart from its role in bone repair, analysis of the bone-forming potential of periosteum-derived stem cells is lacking. Hence, this article elucidates the role of the periosteum as a potential source of mesenchymal stem cells along with their capacity for osteogenic and chondrogenic differentiation for therapeutic application in the future. |
| first_indexed | 2024-03-10T05:10:22Z |
| format | Article |
| id | doaj.art-d294a541ec8148c184db7a2d2a201765 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T05:10:22Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-d294a541ec8148c184db7a2d2a2017652023-11-23T00:55:44ZengMDPI AGPharmaceuticals1424-82472021-11-011411113310.3390/ph14111133Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future?Madhan Jeyaraman0Sathish Muthu1Prakash Gangadaran2Rajni Ranjan3Naveen Jeyaraman4Gollahalli Shivashankar Prajwal5Prabhu Chandra Mishra6Ramya Lakshmi Rajendran7Byeong-Cheol Ahn8Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida 201306, Uttar Pradesh, IndiaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, Uttar Pradesh, IndiaBK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, KoreaDepartment of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida 201306, Uttar Pradesh, IndiaDepartment of Orthopaedics, Atlas Hospitals, Tiruchirappalli 620002, Tamil Nadu, IndiaDepartment of Orthopaedics, Mallika Spine Centre, Guntur 522001, Andhra Pradesh, IndiaInternational Association of Stem Cell and Regenerative Medicine (IASRM), Greater Kailash, New Delhi 110048, Uttar Pradesh, IndiaDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, KoreaBK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, KoreaThe periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix environment. Their role in union and remodeling of fracture is well known. However, the periosteum as a source of mesenchymal stem cells has not been explored in detail. Moreover, with the continuous expansion of techniques, newer insights have been acquired into the roles and regulation of these periosteal cells. From a therapeutic standpoint, the periosteum as a source of tissue engineering has gained much attraction. Apart from its role in bone repair, analysis of the bone-forming potential of periosteum-derived stem cells is lacking. Hence, this article elucidates the role of the periosteum as a potential source of mesenchymal stem cells along with their capacity for osteogenic and chondrogenic differentiation for therapeutic application in the future.https://www.mdpi.com/1424-8247/14/11/1133periosteummesenchymal stromal cellschondrogenesisosteogenesis |
| spellingShingle | Madhan Jeyaraman Sathish Muthu Prakash Gangadaran Rajni Ranjan Naveen Jeyaraman Gollahalli Shivashankar Prajwal Prabhu Chandra Mishra Ramya Lakshmi Rajendran Byeong-Cheol Ahn Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? Pharmaceuticals periosteum mesenchymal stromal cells chondrogenesis osteogenesis |
| title | Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? |
| title_full | Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? |
| title_fullStr | Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? |
| title_full_unstemmed | Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? |
| title_short | Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? |
| title_sort | osteogenic and chondrogenic potential of periosteum derived mesenchymal stromal cells do they hold the key to the future |
| topic | periosteum mesenchymal stromal cells chondrogenesis osteogenesis |
| url | https://www.mdpi.com/1424-8247/14/11/1133 |
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