Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation
Objective: This study aimed to analyze the perinatal changes of plasma estradiol (E2) and angiotensin II (Ang II) in pregnant women with pulmonary arterial hypertension before and after cesarean section. Methods: Depending on pulmonary arterial pressure, the subjects were divided into two groups, mo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-07-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2019.1625365 |
| _version_ | 1797681548287279104 |
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| author | Yanshuang Wang Hao Che Kai Kang Guosheng Zhao Xiaoguang Li Xiangming Che Mingjun Xu Liyun Zhao |
| author_facet | Yanshuang Wang Hao Che Kai Kang Guosheng Zhao Xiaoguang Li Xiangming Che Mingjun Xu Liyun Zhao |
| author_sort | Yanshuang Wang |
| collection | DOAJ |
| description | Objective: This study aimed to analyze the perinatal changes of plasma estradiol (E2) and angiotensin II (Ang II) in pregnant women with pulmonary arterial hypertension before and after cesarean section. Methods: Depending on pulmonary arterial pressure, the subjects were divided into two groups, moderate group, and severe group. Plasma concentrations of E2 and Ang II were determined at different time points using electrochemiluminescence immunoassay and ELISA, respectively. The correlation between E2 and Ang II concentrations was analyzed. Results: Intragroup comparison indicated that E2 levels at different time points after surgery decreased in the two groups than before, with a greater reduction in the severe group. Besides, both groups showed a reduction in Ang II concentrations after surgery. As indicated by intragroup comparison, there was a significant difference at each time point in the two groups. The reduction in Ang II concentrations was more conspicuous at 48 h and 72 h after surgery (cesarean section) than before for the two groups. Moreover, E2 concentrations were correlated positively with AngII concentrations. Conclusion: Plasma concentrations of E2 and Ang II decreased after delivery. The plasma concentrations of E2 and Ang II were correlated with each other. |
| first_indexed | 2024-03-11T23:46:27Z |
| format | Article |
| id | doaj.art-d29504d6658d4872890c89e4c1eab1e2 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:46:27Z |
| publishDate | 2019-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-d29504d6658d4872890c89e4c1eab1e22023-09-19T09:24:43ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652019-07-0138316317010.1080/10641955.2019.16253651625365Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlationYanshuang Wang0Hao Che1Kai Kang2Guosheng Zhao3Xiaoguang Li4Xiangming Che5Mingjun Xu6Liyun Zhao7Beijing Obstetrics and Gynecology Hospital, Capital Medical UniversityBeijing Anzhen Hospital China Capital Medical UniversityBeijing Obstetrics and Gynecology Hospital, Capital Medical UniversityBeijing Obstetrics and Gynecology Hospital, Capital Medical UniversityBeijing Obstetrics and Gynecology Hospital, Capital Medical UniversityBeijing Obstetrics and Gynecology Hospital, Capital Medical UniversityBeijing Obstetrics and Gynecology Hospital, Capital Medical UniversityBeijing Anzhen Hospital China Capital Medical UniversityObjective: This study aimed to analyze the perinatal changes of plasma estradiol (E2) and angiotensin II (Ang II) in pregnant women with pulmonary arterial hypertension before and after cesarean section. Methods: Depending on pulmonary arterial pressure, the subjects were divided into two groups, moderate group, and severe group. Plasma concentrations of E2 and Ang II were determined at different time points using electrochemiluminescence immunoassay and ELISA, respectively. The correlation between E2 and Ang II concentrations was analyzed. Results: Intragroup comparison indicated that E2 levels at different time points after surgery decreased in the two groups than before, with a greater reduction in the severe group. Besides, both groups showed a reduction in Ang II concentrations after surgery. As indicated by intragroup comparison, there was a significant difference at each time point in the two groups. The reduction in Ang II concentrations was more conspicuous at 48 h and 72 h after surgery (cesarean section) than before for the two groups. Moreover, E2 concentrations were correlated positively with AngII concentrations. Conclusion: Plasma concentrations of E2 and Ang II decreased after delivery. The plasma concentrations of E2 and Ang II were correlated with each other.http://dx.doi.org/10.1080/10641955.2019.1625365pregnancypulmonary arterial hypertensioncesarean sectionestradiolangiotensin |
| spellingShingle | Yanshuang Wang Hao Che Kai Kang Guosheng Zhao Xiaoguang Li Xiangming Che Mingjun Xu Liyun Zhao Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation Hypertension in Pregnancy pregnancy pulmonary arterial hypertension cesarean section estradiol angiotensin |
| title | Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation |
| title_full | Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation |
| title_fullStr | Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation |
| title_full_unstemmed | Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation |
| title_short | Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation |
| title_sort | perinatal changes in estradiol and ang ii concentrations in pregnant women with pulmonary arterial hypertension and their correlation |
| topic | pregnancy pulmonary arterial hypertension cesarean section estradiol angiotensin |
| url | http://dx.doi.org/10.1080/10641955.2019.1625365 |
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