Early detection of subjects at risk for vascular remodelling – results from the Swiss population-based study SAPALDIA
QUESTIONS UNDER STUDY: As the burden of cardiovascular disease (CVD) increases globally, its prevention and risk assessment becomes ever more important. We thus investigated the longitudinal association of the cardiovascular risk scores in the population-based cohort SAPALDIA with carotid intima m...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2014-10-01
|
| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/1930 |
| _version_ | 1826997384369930240 |
|---|---|
| author | Julia Dratva Seraina Caviezel Emmanuel Schaffner Elisabeth Zemp Eric de Groot Arno Schmidt-Trucksäss Robert Bettschart Lanja Saleh Alexander Turk Jean-Michel Gaspoz David Carballo Nino Kuenzli Nicole Probst-Hensch |
| author_facet | Julia Dratva Seraina Caviezel Emmanuel Schaffner Elisabeth Zemp Eric de Groot Arno Schmidt-Trucksäss Robert Bettschart Lanja Saleh Alexander Turk Jean-Michel Gaspoz David Carballo Nino Kuenzli Nicole Probst-Hensch |
| author_sort | Julia Dratva |
| collection | DOAJ |
| description |
QUESTIONS UNDER STUDY: As the burden of cardiovascular disease (CVD) increases globally, its prevention and risk assessment becomes ever more important. We thus investigated the longitudinal association of the cardiovascular risk scores in the population-based cohort SAPALDIA with carotid intima media thickening (CIMT), an indicator of sub-clinical disease, and CVD incidence.
METHODS: In 2,832 SAPALDIA participants, the Swiss and ESC heart risk score (AGLA, SCORE) were calculated based on 2001 data and CIMT was measured in 2010/11. We ran multi-level linear regression analyses between scores and CIMT, stratified for CVD status and gender, and logistic analyses for doctor-diagnosed CVD incidence. Path analyses investigated direct and indirect effects on CIMT.
RESULTS: AGLA and SCORE were positively associated with increasing CIMT in both healthy and CVD diagnosed subjects and men and women. Participants in highest risk categories showed a significant CIMT difference of >0.20 mm compared to the reference risk category (<1%), even larger in CVD healthy subjects and men. With increasing risk the odds of CVD incidence increased (Ref. <1%; 10 yr. risk AGLA >10% OR 2.1, >20% OR 3.7). Path analyses yield risk factors’ direct and indirect effects through blood pressure.
CONCLUSION: The positive longitudinal association between risk estimations and CIMT confirms the use of risk scores in assessing individuals and populations at risk. Systolic blood pressure appears to be a main pathological mechanism, underscoring the importance of optimal blood pressure control and the importance of prevention strategies of risk factors, indirectly affecting CIMT through the haemodynamic pathway.
|
| first_indexed | 2024-04-12T00:21:43Z |
| format | Article |
| id | doaj.art-d29677d43a52423399bb000e70d6dee2 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2025-02-18T09:58:30Z |
| publishDate | 2014-10-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-d29677d43a52423399bb000e70d6dee22024-11-02T08:54:51ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972014-10-01144434410.4414/smw.2014.14052Early detection of subjects at risk for vascular remodelling – results from the Swiss population-based study SAPALDIAJulia DratvaSeraina CaviezelEmmanuel SchaffnerElisabeth ZempEric de GrootArno Schmidt-TrucksässRobert BettschartLanja SalehAlexander TurkJean-Michel GaspozDavid CarballoNino KuenzliNicole Probst-Hensch QUESTIONS UNDER STUDY: As the burden of cardiovascular disease (CVD) increases globally, its prevention and risk assessment becomes ever more important. We thus investigated the longitudinal association of the cardiovascular risk scores in the population-based cohort SAPALDIA with carotid intima media thickening (CIMT), an indicator of sub-clinical disease, and CVD incidence. METHODS: In 2,832 SAPALDIA participants, the Swiss and ESC heart risk score (AGLA, SCORE) were calculated based on 2001 data and CIMT was measured in 2010/11. We ran multi-level linear regression analyses between scores and CIMT, stratified for CVD status and gender, and logistic analyses for doctor-diagnosed CVD incidence. Path analyses investigated direct and indirect effects on CIMT. RESULTS: AGLA and SCORE were positively associated with increasing CIMT in both healthy and CVD diagnosed subjects and men and women. Participants in highest risk categories showed a significant CIMT difference of >0.20 mm compared to the reference risk category (<1%), even larger in CVD healthy subjects and men. With increasing risk the odds of CVD incidence increased (Ref. <1%; 10 yr. risk AGLA >10% OR 2.1, >20% OR 3.7). Path analyses yield risk factors’ direct and indirect effects through blood pressure. CONCLUSION: The positive longitudinal association between risk estimations and CIMT confirms the use of risk scores in assessing individuals and populations at risk. Systolic blood pressure appears to be a main pathological mechanism, underscoring the importance of optimal blood pressure control and the importance of prevention strategies of risk factors, indirectly affecting CIMT through the haemodynamic pathway. https://www.smw.ch/index.php/smw/article/view/1930Cardiovascular diseasePreventionblood pressureEpidemiologycardiovascular risk scorecarotid intima media thickness |
| spellingShingle | Julia Dratva Seraina Caviezel Emmanuel Schaffner Elisabeth Zemp Eric de Groot Arno Schmidt-Trucksäss Robert Bettschart Lanja Saleh Alexander Turk Jean-Michel Gaspoz David Carballo Nino Kuenzli Nicole Probst-Hensch Early detection of subjects at risk for vascular remodelling – results from the Swiss population-based study SAPALDIA Swiss Medical Weekly Cardiovascular disease Prevention blood pressure Epidemiology cardiovascular risk score carotid intima media thickness |
| title | Early detection of subjects at risk for vascular remodelling – results from the Swiss population-based study SAPALDIA |
| title_full | Early detection of subjects at risk for vascular remodelling – results from the Swiss population-based study SAPALDIA |
| title_fullStr | Early detection of subjects at risk for vascular remodelling – results from the Swiss population-based study SAPALDIA |
| title_full_unstemmed | Early detection of subjects at risk for vascular remodelling – results from the Swiss population-based study SAPALDIA |
| title_short | Early detection of subjects at risk for vascular remodelling – results from the Swiss population-based study SAPALDIA |
| title_sort | early detection of subjects at risk for vascular remodelling results from the swiss population based study sapaldia |
| topic | Cardiovascular disease Prevention blood pressure Epidemiology cardiovascular risk score carotid intima media thickness |
| url | https://www.smw.ch/index.php/smw/article/view/1930 |
| work_keys_str_mv | AT juliadratva earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT serainacaviezel earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT emmanuelschaffner earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT elisabethzemp earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT ericdegroot earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT arnoschmidttrucksass earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT robertbettschart earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT lanjasaleh earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT alexanderturk earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT jeanmichelgaspoz earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT davidcarballo earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT ninokuenzli earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia AT nicoleprobsthensch earlydetectionofsubjectsatriskforvascularremodellingresultsfromtheswisspopulationbasedstudysapaldia |