Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome
The cholinergic heat-labile neurotoxin produced by Clostridium species is primarily responsible for the clinical manifestations of botulism. The classic phenotypic presentation of botulism consists of subacute descending flaccid paralysis with intact sensory function. Traditionally, it is classified...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-09-01
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| Series: | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542454818300523 |
| _version_ | 1818933432424595456 |
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| author | Pramod K. Guru, MBBS, MD Tara L. Becker, MD Alana Stephens, DO Rocco J. Cannistraro, MD Benjamin H. Eidelman, MD D. Jane Hata, PhD Lisa Brumble, MD |
| author_facet | Pramod K. Guru, MBBS, MD Tara L. Becker, MD Alana Stephens, DO Rocco J. Cannistraro, MD Benjamin H. Eidelman, MD D. Jane Hata, PhD Lisa Brumble, MD |
| author_sort | Pramod K. Guru, MBBS, MD |
| collection | DOAJ |
| description | The cholinergic heat-labile neurotoxin produced by Clostridium species is primarily responsible for the clinical manifestations of botulism. The classic phenotypic presentation of botulism consists of subacute descending flaccid paralysis with intact sensory function. Traditionally, it is classified into 3 main forms (foodborne, wound-related, and infantile) on the basis of primary site of toxin entry into the human nervous system. Toxemia is the common pathophysiology in all forms of botulism. Adult intestinal toxemia botulism is an extremely rare form of the disease with pathogenesis similar to that of infant-type botulism. Symptomatic adults usually have an anatomic abnormality in the gastrointestinal tract leading to changes in normal gut flora. The current case is an addition to the growing literature on this unusual clinical variant of botulism. |
| first_indexed | 2024-12-20T04:48:17Z |
| format | Article |
| id | doaj.art-d296a951feb5473aa631f4db77617ecb |
| institution | Directory Open Access Journal |
| issn | 2542-4548 |
| language | English |
| last_indexed | 2024-12-20T04:48:17Z |
| publishDate | 2018-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| spelling | doaj.art-d296a951feb5473aa631f4db77617ecb2022-12-21T19:52:55ZengElsevierMayo Clinic Proceedings: Innovations, Quality & Outcomes2542-45482018-09-0123291296Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel SyndromePramod K. Guru, MBBS, MD0Tara L. Becker, MD1Alana Stephens, DO2Rocco J. Cannistraro, MD3Benjamin H. Eidelman, MD4D. Jane Hata, PhD5Lisa Brumble, MD6Department of Critical Care Medicine, Mayo Clinic, Jacksonville, FL; Correspondence: Address to Pramod K. Guru, MD, MBBS, Department of Critical Care Medicine, Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL 32224.Department of Neurology, Mayo Clinic, Jacksonville, FLDepartment of Neurology, Mayo Clinic, Jacksonville, FLDepartment of Neurology, Mayo Clinic, Jacksonville, FLDepartment of Neurology, Mayo Clinic, Jacksonville, FLDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FLDivision of Infectious Diseases, Mayo Clinic, Jacksonville, FLThe cholinergic heat-labile neurotoxin produced by Clostridium species is primarily responsible for the clinical manifestations of botulism. The classic phenotypic presentation of botulism consists of subacute descending flaccid paralysis with intact sensory function. Traditionally, it is classified into 3 main forms (foodborne, wound-related, and infantile) on the basis of primary site of toxin entry into the human nervous system. Toxemia is the common pathophysiology in all forms of botulism. Adult intestinal toxemia botulism is an extremely rare form of the disease with pathogenesis similar to that of infant-type botulism. Symptomatic adults usually have an anatomic abnormality in the gastrointestinal tract leading to changes in normal gut flora. The current case is an addition to the growing literature on this unusual clinical variant of botulism.http://www.sciencedirect.com/science/article/pii/S2542454818300523 |
| spellingShingle | Pramod K. Guru, MBBS, MD Tara L. Becker, MD Alana Stephens, DO Rocco J. Cannistraro, MD Benjamin H. Eidelman, MD D. Jane Hata, PhD Lisa Brumble, MD Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| title | Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome |
| title_full | Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome |
| title_fullStr | Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome |
| title_full_unstemmed | Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome |
| title_short | Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome |
| title_sort | adult intestinal botulism a rare presentation in an immunocompromised patient with short bowel syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2542454818300523 |
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