LITHIUM SALTS IN EXPERIMENTAL ONCOLOGY (REVIEW)
Recently, lithium salts have been considered as potential compounds for targeted therapy that can reduce tumor growth. There are a large number of publications indicating the effects of lithium on the signaling pathways used by tumor cells for growth and development, and have demonstrated that lithi...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2019-11-01
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| Series: | Сибирский научный медицинский журнал |
| Subjects: | |
| Online Access: | https://sibmed.elpub.ru/jour/article/view/270 |
| _version_ | 1797269559199137792 |
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| author | Iu. S. Taskaeva N. P. Bgatova |
| author_facet | Iu. S. Taskaeva N. P. Bgatova |
| author_sort | Iu. S. Taskaeva |
| collection | DOAJ |
| description | Recently, lithium salts have been considered as potential compounds for targeted therapy that can reduce tumor growth. There are a large number of publications indicating the effects of lithium on the signaling pathways used by tumor cells for growth and development, and have demonstrated that lithium can be used as antitumor agent in experimental oncology. The promise of using lithium salts to develop anticancer drugs is related to the fact that lithium has 2 main intracellular targets: glycogen synthase kinase-3β (GSK-3β) and inositol monophosphatase (IMPase), the inhibition of which by lithium can induce cancer cell death by apoptosis or autophagy. Lithium has been shown to block the proliferation of cancer cells by cell cycle arrest in the G2 /M phase, and also stimulates apoptosis and autophagy in cancer cells. This review summarizes data on the transport of lithium across cell membranes, characterizes its main intracellular targets and presents the results of studies in which lithium was used in experimental cancer therapy of various localization with an emphasis on signaling pathways used by cancer cells for growth and metastasis. |
| first_indexed | 2024-03-08T14:34:33Z |
| format | Article |
| id | doaj.art-d297b3e178054581b55c5612bb6d5020 |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2024-04-25T01:50:18Z |
| publishDate | 2019-11-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-d297b3e178054581b55c5612bb6d50202024-03-07T18:49:58ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202019-11-01395121810.15372/SSMJ20190502183LITHIUM SALTS IN EXPERIMENTAL ONCOLOGY (REVIEW)Iu. S. Taskaeva0N. P. Bgatova1Research Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RAS, Novosibirsk State UniversityResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASRecently, lithium salts have been considered as potential compounds for targeted therapy that can reduce tumor growth. There are a large number of publications indicating the effects of lithium on the signaling pathways used by tumor cells for growth and development, and have demonstrated that lithium can be used as antitumor agent in experimental oncology. The promise of using lithium salts to develop anticancer drugs is related to the fact that lithium has 2 main intracellular targets: glycogen synthase kinase-3β (GSK-3β) and inositol monophosphatase (IMPase), the inhibition of which by lithium can induce cancer cell death by apoptosis or autophagy. Lithium has been shown to block the proliferation of cancer cells by cell cycle arrest in the G2 /M phase, and also stimulates apoptosis and autophagy in cancer cells. This review summarizes data on the transport of lithium across cell membranes, characterizes its main intracellular targets and presents the results of studies in which lithium was used in experimental cancer therapy of various localization with an emphasis on signaling pathways used by cancer cells for growth and metastasis.https://sibmed.elpub.ru/jour/article/view/270experimental oncologylithium saltsgsk-3βimpaseapoptosisautophagy |
| spellingShingle | Iu. S. Taskaeva N. P. Bgatova LITHIUM SALTS IN EXPERIMENTAL ONCOLOGY (REVIEW) Сибирский научный медицинский журнал experimental oncology lithium salts gsk-3β impase apoptosis autophagy |
| title | LITHIUM SALTS IN EXPERIMENTAL ONCOLOGY (REVIEW) |
| title_full | LITHIUM SALTS IN EXPERIMENTAL ONCOLOGY (REVIEW) |
| title_fullStr | LITHIUM SALTS IN EXPERIMENTAL ONCOLOGY (REVIEW) |
| title_full_unstemmed | LITHIUM SALTS IN EXPERIMENTAL ONCOLOGY (REVIEW) |
| title_short | LITHIUM SALTS IN EXPERIMENTAL ONCOLOGY (REVIEW) |
| title_sort | lithium salts in experimental oncology review |
| topic | experimental oncology lithium salts gsk-3β impase apoptosis autophagy |
| url | https://sibmed.elpub.ru/jour/article/view/270 |
| work_keys_str_mv | AT iustaskaeva lithiumsaltsinexperimentaloncologyreview AT npbgatova lithiumsaltsinexperimentaloncologyreview |