Efficient simulation of clinical target response surfaces

Efficient simulation of clinical target response surfaces

Abstract Simulation of combination therapies is challenging due to computational complexity. Either a simple model is used to simulate the response for many combinations of concentration to generate a response surface but parameter variability and uncertainty are neglected and the concentrations are...

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Bibliographic Details
Main Authors:	Daniel Lill, Anne Kümmel, Venelin Mitov, Daniel Kaschek, Nathalie Gobeau, Henning Schmidt, Jens Timmer
Format:	Article
Language:	English
Published:	Wiley 2022-04-01
Series:	CPT: Pharmacometrics & Systems Pharmacology
Online Access:	https://doi.org/10.1002/psp4.12779

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