Radiosensitizer Effect of β-Apopicropodophyllin against Colorectal Cancer via Induction of Reactive Oxygen Species and Apoptosis

Radiosensitizer Effect of β-Apopicropodophyllin against Colorectal Cancer via Induction of Reactive Oxygen Species and Apoptosis

β-apopicropodophyllin (APP), a derivative of podophyllotoxin (PPT), has been identified as a potential anti-cancer drug. This study tested whether APP acts as an anti-cancer drug and can sensitize colorectal cancer (CRC) cells to radiation treatment. APP exerted an anti-cancer effect against the CRC...

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Bibliographic Details
Main Authors: Jin-Hee Kwon, Na-Gyeong Lee, A-Ram Kang, Jie-Young Song, Sang-Gu Hwang, Hong-Duck Um, Joon Kim, Jong Kuk Park
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
β-apopicropodophyllin
radiosensitizer
topoisomerase inhibitor
ROS
apoptosis
colorectal cancer
Online Access:https://www.mdpi.com/1422-0067/22/24/13514

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