Mutations in immunodeficiency-related genes may increase the risk of infection after CAR-T-cell therapy: a report of two cases

Mutations in immunodeficiency-related genes may increase the risk of infection after CAR-T-cell therapy: a report of two cases

Abstract Background Chimeric antigen receptor T-cell therapy (CAR-T) has yielded unprecedented efficacy in B-cell malignancies. With the increasing use of CAR-T-cell therapy, infection has become one of the major concerns after CAR-T-cell infusion. Some patients even develop refractory or recurrent...

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Bibliographic Details
Main Authors: Di Wang, Li He, Chunhui Li, Menglei Xu, Qiuxia Yu, Varlene Daniela Fernandes Almeida, Yimei Que, Yanjie Xu, Yi Xiao, Chunrui Li
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Infectious Diseases
Subjects:
CAR-T
Infection
Gene mutations
Sequencing
Immunodeficiency
Online Access:https://doi.org/10.1186/s12879-023-08070-w

Internet

https://doi.org/10.1186/s12879-023-08070-w

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