Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions
Abstract Background The efficacy of immune checkpoint blockade in the treatment of microsatellite instability (MSI)-high tumors was recently reported. Therefore, the acquisition of histological specimens is desired in cases of unresectable solid pancreatic lesions (UR SPLs). This study investigated...
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-020-07588-5 |
| _version_ | 1828869191479853056 |
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| author | Mitsuru Sugimoto Hiroki Irie Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Jun Nakamura Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Yasuyuki Kobayashi Yuko Hashimoto Takuto Hikichi Hiromasa Ohira |
| author_facet | Mitsuru Sugimoto Hiroki Irie Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Jun Nakamura Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Yasuyuki Kobayashi Yuko Hashimoto Takuto Hikichi Hiromasa Ohira |
| author_sort | Mitsuru Sugimoto |
| collection | DOAJ |
| description | Abstract Background The efficacy of immune checkpoint blockade in the treatment of microsatellite instability (MSI)-high tumors was recently reported. Therefore, the acquisition of histological specimens is desired in cases of unresectable solid pancreatic lesions (UR SPLs). This study investigated the efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needle for UR SPL tissue acquisition and MSI evaluation. Methods A total of 195 SPL patients who underwent EUS-guided fine-needle aspiration (EUS-FNA) or EUS-FNB (EUS-FNAB) between January 2017 and March 2020 were enrolled in this study. Among them, 89 SPL patients (FNB: 28, FNA: 61) underwent EUS-FNAB using a 22-G needle (UR SPLs: 58, FNB: 22, FNA: 36) (UR SPLs after starting MSI evaluation: 23, FNB: 9, FNA: 14). Results The puncture number was significantly lower with FNB than with FNA (median (range): 3 (2–5) vs 4 (1–8), P < 0.01, UR SPLs: 3 (2–5) vs 4 (1–8), P = 0.036). Histological specimen acquisition was more commonly achieved with FNB than with FNA (92.9% (26/28) vs 68.9% (42/61), P = 0.015, UR SPLs: 100% (22/22) vs 72.2% (26/36), P < 0.01). The histological specimen required for MSI evaluation was acquired more often with FNB than with FNA (88.9% (8/9) vs 35.7% (5/14), P = 0.03). Conclusions EUS-FNB using a Franseen needle is efficient for histological specimen acquisition and sampling the required amount of specimen for MSI evaluation in UR SPL patients. |
| first_indexed | 2024-12-13T05:45:40Z |
| format | Article |
| id | doaj.art-d29cf63bc7b5447b9b4a9471d308a428 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-13T05:45:40Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj.art-d29cf63bc7b5447b9b4a9471d308a4282022-12-21T23:57:41ZengBMCBMC Cancer1471-24072020-11-012011710.1186/s12885-020-07588-5Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesionsMitsuru Sugimoto0Hiroki Irie1Tadayuki Takagi2Rei Suzuki3Naoki Konno4Hiroyuki Asama5Yuki Sato6Jun Nakamura7Mika Takasumi8Minami Hashimoto9Tsunetaka Kato10Ryoichiro Kobashi11Yasuyuki Kobayashi12Yuko Hashimoto13Takuto Hikichi14Hiromasa Ohira15Department of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Gastroenterology, Fukushima Medical University, School of MedicineDepartment of Diagnostic Pathology, Fukushima Medical University, School of MedicineDepartment of Diagnostic Pathology, Fukushima Medical University, School of MedicineDepartment of Endoscopy, Fukushima Medical University HospitalDepartment of Gastroenterology, Fukushima Medical University, School of MedicineAbstract Background The efficacy of immune checkpoint blockade in the treatment of microsatellite instability (MSI)-high tumors was recently reported. Therefore, the acquisition of histological specimens is desired in cases of unresectable solid pancreatic lesions (UR SPLs). This study investigated the efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needle for UR SPL tissue acquisition and MSI evaluation. Methods A total of 195 SPL patients who underwent EUS-guided fine-needle aspiration (EUS-FNA) or EUS-FNB (EUS-FNAB) between January 2017 and March 2020 were enrolled in this study. Among them, 89 SPL patients (FNB: 28, FNA: 61) underwent EUS-FNAB using a 22-G needle (UR SPLs: 58, FNB: 22, FNA: 36) (UR SPLs after starting MSI evaluation: 23, FNB: 9, FNA: 14). Results The puncture number was significantly lower with FNB than with FNA (median (range): 3 (2–5) vs 4 (1–8), P < 0.01, UR SPLs: 3 (2–5) vs 4 (1–8), P = 0.036). Histological specimen acquisition was more commonly achieved with FNB than with FNA (92.9% (26/28) vs 68.9% (42/61), P = 0.015, UR SPLs: 100% (22/22) vs 72.2% (26/36), P < 0.01). The histological specimen required for MSI evaluation was acquired more often with FNB than with FNA (88.9% (8/9) vs 35.7% (5/14), P = 0.03). Conclusions EUS-FNB using a Franseen needle is efficient for histological specimen acquisition and sampling the required amount of specimen for MSI evaluation in UR SPL patients.http://link.springer.com/article/10.1186/s12885-020-07588-5EUS-FNAEUS-FNBUnresectable pancreatic lesionMicrosatellite instability |
| spellingShingle | Mitsuru Sugimoto Hiroki Irie Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Jun Nakamura Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Yasuyuki Kobayashi Yuko Hashimoto Takuto Hikichi Hiromasa Ohira Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions BMC Cancer EUS-FNA EUS-FNB Unresectable pancreatic lesion Microsatellite instability |
| title | Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions |
| title_full | Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions |
| title_fullStr | Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions |
| title_full_unstemmed | Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions |
| title_short | Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions |
| title_sort | efficacy of eus guided fnb using a franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions |
| topic | EUS-FNA EUS-FNB Unresectable pancreatic lesion Microsatellite instability |
| url | http://link.springer.com/article/10.1186/s12885-020-07588-5 |
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