Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies
Abstract Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction. We investigated glycocalyx components in relation to preeclampsia in...
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| Format: | Article |
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Nature Portfolio
2021-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-82972-0 |
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| author | H. Hassani Lahsinoui F. Amraoui L. J. A. Spijkers G. J. M. Veenboer S. L. M. Peters N. van Vlies L. Vogt C. Ris-Stalpers B. J. H. van den Born G. B. Afink |
| author_facet | H. Hassani Lahsinoui F. Amraoui L. J. A. Spijkers G. J. M. Veenboer S. L. M. Peters N. van Vlies L. Vogt C. Ris-Stalpers B. J. H. van den Born G. B. Afink |
| author_sort | H. Hassani Lahsinoui |
| collection | DOAJ |
| description | Abstract Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction. We investigated glycocalyx components in relation to preeclampsia in human samples. While soluble syndecan-1 and heparan sulphate were similar in plasma of preeclamptic and normotensive pregnant women, dermatan sulphate was increased and keratan sulphate decreased in preeclamptic women. Dermatan sulphate was correlated with soluble syndecan-1, and inversely correlated with blood pressure and activated partial thromboplastin time. To determine if syndecan-1 was a prerequisite for the sFlt1 induced increase in blood pressure in mice we studied the effect of sFlt1 on blood pressure and vascular contractile responses in syndecan-1 deficient and wild type male mice. The classical sFlt1 induced rise in blood pressure was absent in syndecan-1 deficient mice indicating that syndecan-1 is a prerequisite for sFlt1 induced increase in blood pressure central to preeclampsia. The results show that an interplay between syndecan-1 and dermatan sulphate contributes to sFlt1 induced blood pressure elevation in pre-eclampsia. |
| first_indexed | 2024-12-14T06:35:14Z |
| format | Article |
| id | doaj.art-d29d07250c854ff189694cdfc477c593 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T06:35:14Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d29d07250c854ff189694cdfc477c5932022-12-21T23:13:23ZengNature PortfolioScientific Reports2045-23222021-02-0111111010.1038/s41598-021-82972-0Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnanciesH. Hassani Lahsinoui0F. Amraoui1L. J. A. Spijkers2G. J. M. Veenboer3S. L. M. Peters4N. van Vlies5L. Vogt6C. Ris-Stalpers7B. J. H. van den Born8G. B. Afink9Department of Obstetrics and Gynaecology, Amsterdam University Medical Centers, University of AmsterdamDepartment of Vascular Medicine, Amsterdam University Medical Centers, University of AmsterdamDepartment of Vascular Medicine, Amsterdam University Medical Centers, University of AmsterdamReproductive Biology Laboratory, Amsterdam University Medical Centers, University of AmsterdamDepartment of Vascular Medicine, Amsterdam University Medical Centers, University of AmsterdamLaboratory Genetic Metabolic Diseases, Amsterdam University Medical Centers, University of AmsterdamDepartment of Vascular Medicine, Amsterdam University Medical Centers, University of AmsterdamDepartment of Obstetrics and Gynaecology, Amsterdam University Medical Centers, University of AmsterdamDepartment of Vascular Medicine, Amsterdam University Medical Centers, University of AmsterdamReproductive Biology Laboratory, Amsterdam University Medical Centers, University of AmsterdamAbstract Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction. We investigated glycocalyx components in relation to preeclampsia in human samples. While soluble syndecan-1 and heparan sulphate were similar in plasma of preeclamptic and normotensive pregnant women, dermatan sulphate was increased and keratan sulphate decreased in preeclamptic women. Dermatan sulphate was correlated with soluble syndecan-1, and inversely correlated with blood pressure and activated partial thromboplastin time. To determine if syndecan-1 was a prerequisite for the sFlt1 induced increase in blood pressure in mice we studied the effect of sFlt1 on blood pressure and vascular contractile responses in syndecan-1 deficient and wild type male mice. The classical sFlt1 induced rise in blood pressure was absent in syndecan-1 deficient mice indicating that syndecan-1 is a prerequisite for sFlt1 induced increase in blood pressure central to preeclampsia. The results show that an interplay between syndecan-1 and dermatan sulphate contributes to sFlt1 induced blood pressure elevation in pre-eclampsia.https://doi.org/10.1038/s41598-021-82972-0 |
| spellingShingle | H. Hassani Lahsinoui F. Amraoui L. J. A. Spijkers G. J. M. Veenboer S. L. M. Peters N. van Vlies L. Vogt C. Ris-Stalpers B. J. H. van den Born G. B. Afink Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies Scientific Reports |
| title | Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies |
| title_full | Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies |
| title_fullStr | Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies |
| title_full_unstemmed | Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies |
| title_short | Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies |
| title_sort | soluble syndecan 1 and glycosaminoglycans in preeclamptic and normotensive pregnancies |
| url | https://doi.org/10.1038/s41598-021-82972-0 |
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