Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment
Binita Shrestha,1 Lijun Wang,1 Hao Zhang,2 Chiung Yu Hung,2 Liang Tang1 1Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA; 2Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USACorrespondence: Liang TangDepartment of Bio...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-10-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/gold-nanoparticles-mediated-drug-gene-combinational-therapy-for-breast-peer-reviewed-article-IJN |
| _version_ | 1818424740330602496 |
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| author | Shrestha B Wang L Zhang H Hung CY Tang L |
| author_facet | Shrestha B Wang L Zhang H Hung CY Tang L |
| author_sort | Shrestha B |
| collection | DOAJ |
| description | Binita Shrestha,1 Lijun Wang,1 Hao Zhang,2 Chiung Yu Hung,2 Liang Tang1 1Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA; 2Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USACorrespondence: Liang TangDepartment of Biomedical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USATel +1 210-458-7995Email Liang.Tang@utsa.eduBackground: Cancer is a complex heterogeneous disease to which singular modes of treatment mostly fail to produce a desired therapeutic efficacy. Targeting different cellular pathways using combinational therapies has been gaining popularity in cancer treatment, with the added benefit of reducing dosage and side effects.Methods: A gold nanoparticle-mediated drug delivery nanoplatform was developed for co-delivery of doxorubicin and polo-like kinase 1 (PLK1) siRNA. Gold nanoparticles were coated with polyethyleneimine to facilitate assembly of PLK1 on the surface. Doxorubicin was loaded on nanoparticles through a pH-sensitive linker with a thiol group at one terminal end for controlled release.Results: The therapeutic efficiency of this co-delivery system was evaluated in 2D and 3D cultured systems. The reduced IC50 value clearly demonstrated the synergistic effect of combined drug and gene delivery over their individual delivery in a cancer treatment model.Conclusion: This study may provide an adaptable, facile platform to investigate drug-siRNA combinations for cancer inhibition.Keywords: nanomedicine, cancer therapy, pH-responsive, co-delivery, PLK1 |
| first_indexed | 2024-12-14T14:02:51Z |
| format | Article |
| id | doaj.art-d29e140b39684adabce71c5e6744546a |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-14T14:02:51Z |
| publishDate | 2020-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-d29e140b39684adabce71c5e6744546a2022-12-21T22:58:41ZengDove Medical PressInternational Journal of Nanomedicine1178-20132020-10-01Volume 158109811958362Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer TreatmentShrestha BWang LZhang HHung CYTang LBinita Shrestha,1 Lijun Wang,1 Hao Zhang,2 Chiung Yu Hung,2 Liang Tang1 1Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA; 2Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USACorrespondence: Liang TangDepartment of Biomedical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USATel +1 210-458-7995Email Liang.Tang@utsa.eduBackground: Cancer is a complex heterogeneous disease to which singular modes of treatment mostly fail to produce a desired therapeutic efficacy. Targeting different cellular pathways using combinational therapies has been gaining popularity in cancer treatment, with the added benefit of reducing dosage and side effects.Methods: A gold nanoparticle-mediated drug delivery nanoplatform was developed for co-delivery of doxorubicin and polo-like kinase 1 (PLK1) siRNA. Gold nanoparticles were coated with polyethyleneimine to facilitate assembly of PLK1 on the surface. Doxorubicin was loaded on nanoparticles through a pH-sensitive linker with a thiol group at one terminal end for controlled release.Results: The therapeutic efficiency of this co-delivery system was evaluated in 2D and 3D cultured systems. The reduced IC50 value clearly demonstrated the synergistic effect of combined drug and gene delivery over their individual delivery in a cancer treatment model.Conclusion: This study may provide an adaptable, facile platform to investigate drug-siRNA combinations for cancer inhibition.Keywords: nanomedicine, cancer therapy, pH-responsive, co-delivery, PLK1https://www.dovepress.com/gold-nanoparticles-mediated-drug-gene-combinational-therapy-for-breast-peer-reviewed-article-IJNnanomedicinecancer therapyph-responsiveco-deliveryplk1 |
| spellingShingle | Shrestha B Wang L Zhang H Hung CY Tang L Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment International Journal of Nanomedicine nanomedicine cancer therapy ph-responsive co-delivery plk1 |
| title | Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment |
| title_full | Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment |
| title_fullStr | Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment |
| title_full_unstemmed | Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment |
| title_short | Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment |
| title_sort | gold nanoparticles mediated drug gene combinational therapy for breast cancer treatment |
| topic | nanomedicine cancer therapy ph-responsive co-delivery plk1 |
| url | https://www.dovepress.com/gold-nanoparticles-mediated-drug-gene-combinational-therapy-for-breast-peer-reviewed-article-IJN |
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