Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine
The organisms thriving under extreme conditions better than any other organism living on Earth, fascinate by their hostile growing parameters, physiological features, and their production of valuable bioactive metabolites. This is the case of microorganisms (bacteria, archaea, and fungi) that grow o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-12-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/18/1/33 |
| _version_ | 1817993865519431680 |
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| author | Paulina Corral Mohammad A. Amoozegar Antonio Ventosa |
| author_facet | Paulina Corral Mohammad A. Amoozegar Antonio Ventosa |
| author_sort | Paulina Corral |
| collection | DOAJ |
| description | The organisms thriving under extreme conditions better than any other organism living on Earth, fascinate by their hostile growing parameters, physiological features, and their production of valuable bioactive metabolites. This is the case of microorganisms (bacteria, archaea, and fungi) that grow optimally at high salinities and are able to produce biomolecules of pharmaceutical interest for therapeutic applications. As along as the microbiota is being approached by massive sequencing, novel insights are revealing the environmental conditions on which the compounds are produced in the microbial community without more stress than sharing the same substratum with their peers, the salt. In this review are reported the molecules described and produced by halophilic microorganisms with a spectrum of action in vitro: antimicrobial and anticancer. The action mechanisms of these molecules, the urgent need to introduce alternative lead compounds and the current aspects on the exploitation and its limitations are discussed. |
| first_indexed | 2024-04-14T01:45:23Z |
| format | Article |
| id | doaj.art-d29ea87370af40b8a8334f5194ca9841 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T01:45:23Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-d29ea87370af40b8a8334f5194ca98412022-12-22T02:19:34ZengMDPI AGMarine Drugs1660-33972019-12-011813310.3390/md18010033md18010033Halophiles and Their Biomolecules: Recent Advances and Future Applications in BiomedicinePaulina Corral0Mohammad A. Amoozegar1Antonio Ventosa2Department of Biology, University of Naples Federico II, 80126 Naples, ItalyDepartment of Microbiology, School of Biology, College of Science, University of Tehran, Tehran 14155-6955, IranDepartment of Microbiology and Parasitology, Faculty of Pharmacy, University of Sevilla, 41012 Sevilla, SpainThe organisms thriving under extreme conditions better than any other organism living on Earth, fascinate by their hostile growing parameters, physiological features, and their production of valuable bioactive metabolites. This is the case of microorganisms (bacteria, archaea, and fungi) that grow optimally at high salinities and are able to produce biomolecules of pharmaceutical interest for therapeutic applications. As along as the microbiota is being approached by massive sequencing, novel insights are revealing the environmental conditions on which the compounds are produced in the microbial community without more stress than sharing the same substratum with their peers, the salt. In this review are reported the molecules described and produced by halophilic microorganisms with a spectrum of action in vitro: antimicrobial and anticancer. The action mechanisms of these molecules, the urgent need to introduce alternative lead compounds and the current aspects on the exploitation and its limitations are discussed.https://www.mdpi.com/1660-3397/18/1/33halophilic bacteriaarchaea and fungibiomoleculesbiomedicineantimicrobial compoundsanticancer compounds |
| spellingShingle | Paulina Corral Mohammad A. Amoozegar Antonio Ventosa Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine Marine Drugs halophilic bacteria archaea and fungi biomolecules biomedicine antimicrobial compounds anticancer compounds |
| title | Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine |
| title_full | Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine |
| title_fullStr | Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine |
| title_full_unstemmed | Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine |
| title_short | Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine |
| title_sort | halophiles and their biomolecules recent advances and future applications in biomedicine |
| topic | halophilic bacteria archaea and fungi biomolecules biomedicine antimicrobial compounds anticancer compounds |
| url | https://www.mdpi.com/1660-3397/18/1/33 |
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