Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer

Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer

Indoleamine 2,3-dioxygenase 2 (IDO2) is a tryptophan-catabolizing enzyme and a homolog of IDO1 with a distinct expression pattern compared with IDO1. In dendritic cells (DCs), IDO activity and the resulting changes in tryptophan level regulate T-cell differentiation and promote immune tolerance. Rec...

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Bibliographic Details
Main Authors: Sarah Y. Kado, Keith Bein, Alejandro R. Castaneda, Arshia A. Pouraryan, Nicole Garrity, Yasuhiro Ishihara, Andrea Rossi, Thomas Haarmann-Stemmann, Colleen A. Sweeney, Christoph F. A. Vogel
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
AhR
breast cancer
IDO
IDO2
immunity
TCDD
Online Access:https://www.mdpi.com/2073-4409/12/10/1433

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