Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing.

Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing.

Membrane bound mucins are up-regulated and aberrantly glycosylated during malignant transformation in many cancer cells. This results in a negatively charged glycoprotein coat which may protect cancer cells from immune surveillance. However, only limited data have so far demonstrated the critical st...

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Bibliographic Details
Main Authors: Caroline B Madsen, Kirstine Lavrsen, Catharina Steentoft, Malene B Vester-Christensen, Henrik Clausen, Hans H Wandall, Anders Elm Pedersen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24039759/pdf/?tool=EBI

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