A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model

A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model

The leading cause of treatment failure in Staphylococcus aureus infections is the development of biofilms. Biofilms are highly tolerant to conventional antibiotics which were developed against planktonic cells. Consequently, there is a lack of antibiofilm agents in the antibiotic development pipelin...

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Bibliographic Details
Main Authors: Jessica M. Gilbertie, Thomas P. Schaer, Julie B. Engiles, Gabriela S. Seiler, Bennett L. Deddens, Alicia G. Schubert, Megan E. Jacob, Darko Stefanovski, Gordon Ruthel, Noreen J. Hickok, Devorah M. Stowe, Alexa Frink, Lauren V. Schnabel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
infectious arthritis
S. aureus
biofilm
antimicrobial
platelets
cartilage
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.895022/full

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