Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis
Introduction: Clinical studies of intra-articular injection of mesenchymal stem cells for osteoarthritis (OA) indicate its efficacy. Here, we retrospectively investigated the associations of pretherapeutic magnetic resonance imaging (MRI) findings with the clinical outcomes up to 6 months, after int...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320420300195 |
| _version_ | 1811210714836107264 |
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| author | Junya Higuchi Ryota Yamagami Takumi Matsumoto Tomohiro Terao Keita Inoue Shinsaku Tsuji Yuji Maenohara Tokio Matsuzaki Ryota Chijimatsu Yasunori Omata Fumiko Yano Sakae Tanaka Taku Saito |
| author_facet | Junya Higuchi Ryota Yamagami Takumi Matsumoto Tomohiro Terao Keita Inoue Shinsaku Tsuji Yuji Maenohara Tokio Matsuzaki Ryota Chijimatsu Yasunori Omata Fumiko Yano Sakae Tanaka Taku Saito |
| author_sort | Junya Higuchi |
| collection | DOAJ |
| description | Introduction: Clinical studies of intra-articular injection of mesenchymal stem cells for osteoarthritis (OA) indicate its efficacy. Here, we retrospectively investigated the associations of pretherapeutic magnetic resonance imaging (MRI) findings with the clinical outcomes up to 6 months, after intra-articular administration of adipose-derived stem cells (ASCs) to knee OA patients. Methods: We first analyzed alterations of the visual analog scale (VAS) and knee injury and osteoarthritis outcome score (KOOS) in 57 knees of 34 patients from whom clinical scores were obtained before ASC therapy, and at 1, 3, and 6 months. Among the patients, we further examined MRI findings of 34 knees of 19 patients whose pretherapeutic MRI data were available. Results: The mean improvement of VAS and KOOS-total during 6 months was 2.6 ± 4.0 (from 6.1 ± 2.5 to 3.5 ± 2.9, P < 0.001) and 10.2 ± 12.4 (from 54.4 ± 12.7 to 64.6 ± 13.8, P < 0.01), respectively. Scales related to pain and symptoms improved earlier than those related to activities of daily living (ADL) and sports/recreation. Improvement of VAS and KOOS-sports/recreation was significantly higher in patients with more severe cartilage lesions. Similarly, osteophyte lesions were associated significantly with improvement of VAS and KOOS-ADL, and BML was associated with KOOS-ADL and KOOS-sports/recreation. Conclusions: In intra-articular administration of autologous ASCs for knee OA, improvement of VAS and KOOS-sports/recreation was significantly higher in patients with more severe cartilage lesions. Similarly, osteophyte lesions were associated significantly with improvement of VAS and KOOS-ADL, and BML was associated with KOOS-ADL and KOOS-sports/recreation. Clinical studies with larger numbers of patients and various kinds of data are necessary to predict therapeutic effects. |
| first_indexed | 2024-04-12T05:00:40Z |
| format | Article |
| id | doaj.art-d29fcd965b7049c28b46d3016a501866 |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-04-12T05:00:40Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-d29fcd965b7049c28b46d3016a5018662022-12-22T03:47:01ZengElsevierRegenerative Therapy2352-32042020-06-0114332340Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritisJunya Higuchi0Ryota Yamagami1Takumi Matsumoto2Tomohiro Terao3Keita Inoue4Shinsaku Tsuji5Yuji Maenohara6Tokio Matsuzaki7Ryota Chijimatsu8Yasunori Omata9Fumiko Yano10Sakae Tanaka11Taku Saito12Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanOrthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanOrthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Bone and Cartilage Regenerative Medicine, The University of Tokyo Hospital, Tokyo, JapanAvenue Cell Clinic, Tokyo, JapanAvenue Cell Clinic, Tokyo, JapanAvenue Cell Clinic, Tokyo, JapanOrthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanJapan Biodesign Program, Department of Cardiac Surgery, The University of Tokyo, Tokyo, JapanBone and Cartilage Regenerative Medicine, The University of Tokyo Hospital, Tokyo, JapanOrthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Bone and Cartilage Regenerative Medicine, The University of Tokyo Hospital, Tokyo, JapanBone and Cartilage Regenerative Medicine, The University of Tokyo Hospital, Tokyo, JapanOrthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanOrthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Corresponding author. Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. Fax: +81 3 3818 4082.Introduction: Clinical studies of intra-articular injection of mesenchymal stem cells for osteoarthritis (OA) indicate its efficacy. Here, we retrospectively investigated the associations of pretherapeutic magnetic resonance imaging (MRI) findings with the clinical outcomes up to 6 months, after intra-articular administration of adipose-derived stem cells (ASCs) to knee OA patients. Methods: We first analyzed alterations of the visual analog scale (VAS) and knee injury and osteoarthritis outcome score (KOOS) in 57 knees of 34 patients from whom clinical scores were obtained before ASC therapy, and at 1, 3, and 6 months. Among the patients, we further examined MRI findings of 34 knees of 19 patients whose pretherapeutic MRI data were available. Results: The mean improvement of VAS and KOOS-total during 6 months was 2.6 ± 4.0 (from 6.1 ± 2.5 to 3.5 ± 2.9, P < 0.001) and 10.2 ± 12.4 (from 54.4 ± 12.7 to 64.6 ± 13.8, P < 0.01), respectively. Scales related to pain and symptoms improved earlier than those related to activities of daily living (ADL) and sports/recreation. Improvement of VAS and KOOS-sports/recreation was significantly higher in patients with more severe cartilage lesions. Similarly, osteophyte lesions were associated significantly with improvement of VAS and KOOS-ADL, and BML was associated with KOOS-ADL and KOOS-sports/recreation. Conclusions: In intra-articular administration of autologous ASCs for knee OA, improvement of VAS and KOOS-sports/recreation was significantly higher in patients with more severe cartilage lesions. Similarly, osteophyte lesions were associated significantly with improvement of VAS and KOOS-ADL, and BML was associated with KOOS-ADL and KOOS-sports/recreation. Clinical studies with larger numbers of patients and various kinds of data are necessary to predict therapeutic effects.http://www.sciencedirect.com/science/article/pii/S2352320420300195OsteoarthritisAdipose-derived stem cellIntra-articular administrationVASKOOSMOAKS |
| spellingShingle | Junya Higuchi Ryota Yamagami Takumi Matsumoto Tomohiro Terao Keita Inoue Shinsaku Tsuji Yuji Maenohara Tokio Matsuzaki Ryota Chijimatsu Yasunori Omata Fumiko Yano Sakae Tanaka Taku Saito Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis Regenerative Therapy Osteoarthritis Adipose-derived stem cell Intra-articular administration VAS KOOS MOAKS |
| title | Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis |
| title_full | Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis |
| title_fullStr | Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis |
| title_full_unstemmed | Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis |
| title_short | Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis |
| title_sort | associations of clinical outcomes and mri findings in intra articular administration of autologous adipose derived stem cells for knee osteoarthritis |
| topic | Osteoarthritis Adipose-derived stem cell Intra-articular administration VAS KOOS MOAKS |
| url | http://www.sciencedirect.com/science/article/pii/S2352320420300195 |
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