Exhaled Hydrogen after Lactulose Hydrogen Breath Test in Patient with Duodenal Ulcer Disease—A Pilot Study for <i>Helicobacter-pylori</i>-Associated Gastroduodenal Disease
Objectives: The precipitating mechanism(s) from the inactive to the active stage of duodenal ulcer disease (DU) is unclear. It has been shown that hydrogen gas from colonic fermentation provides an important energy source for <i>Helicobacter pylori</i> (Hp) colonization. The lactulose hy...
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MDPI AG
2022-12-01
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| author | Yi-Hsun Chen Sharon Chia-Ju Chen Jiunn-Wei Wang Chiang-Shin Liu Jeng-Yih Wu Deng-Chyang Wu Yu-Chung Su |
| author_facet | Yi-Hsun Chen Sharon Chia-Ju Chen Jiunn-Wei Wang Chiang-Shin Liu Jeng-Yih Wu Deng-Chyang Wu Yu-Chung Su |
| author_sort | Yi-Hsun Chen |
| collection | DOAJ |
| description | Objectives: The precipitating mechanism(s) from the inactive to the active stage of duodenal ulcer disease (DU) is unclear. It has been shown that hydrogen gas from colonic fermentation provides an important energy source for <i>Helicobacter pylori</i> (Hp) colonization. The lactulose hydrogen breath test (LHBT) is a useful tool to assess the small intestinal and/or colon fermentation. This study examines the association(s) between the status of gastroduodenal disease and the result of a lactulose hydrogen breath test (LHBT). Materials and Methods: We enrolled Hp-positive active duodenal ulcer (aDU) patients, inactive DU (iDU) patients and patients with a positive Hp infection without structural gastroduodenal lesion, i.e., simple gastritis (SG Hp+). The patients with simple gastritis without Hp infection (SG Hp−) served as controls. Histological examinations of the gastric mucosa and lactulose hydrogen breath test (LHBT) were performed. Results: SG Hp+ patients tend to have advanced gastritis (pangastritis or corpus-predominant gastritis) compared with SG Hp− patients (7/29 vs. 0/14, <i>p</i> = 0.08). More iDU patients had advanced gastritis than either the SG Hp+ (7/9 vs. 7/29, <i>p</i> = 0.006) or aDU patients (7/9 vs. 6/24, <i>p</i> = 0.013). In comparison with the aDU patients, the iDU patients were also older (52.1 ± 12.6 vs. 42.2 ± 11.9 years, <i>p</i> = 0.02) and had a lower mean area under the curve value of the LHBT(AUC) (209.1 ± 86.0 vs. 421.9 ± 70.9, <i>p</i> = 0.023). Conclusion: aDU patients with a positive Hp infection have a lower grade of gastric mucosa damage than iDU patients and tend to have a higher level of exhaled hydrogen after LHBT. |
| first_indexed | 2024-03-09T11:57:58Z |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T11:57:58Z |
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| spelling | doaj.art-d2a08035884a43a781e7bade821060d52023-11-30T23:07:12ZengMDPI AGLife2075-17292022-12-011314510.3390/life13010045Exhaled Hydrogen after Lactulose Hydrogen Breath Test in Patient with Duodenal Ulcer Disease—A Pilot Study for <i>Helicobacter-pylori</i>-Associated Gastroduodenal DiseaseYi-Hsun Chen0Sharon Chia-Ju Chen1Jiunn-Wei Wang2Chiang-Shin Liu3Jeng-Yih Wu4Deng-Chyang Wu5Yu-Chung Su6Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City 80756, TaiwanDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung City 80756, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City 80756, TaiwanDepartment of Pathology, National Cheng Kung University Hospital, Tainan 70403, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City 80756, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City 80756, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City 80756, TaiwanObjectives: The precipitating mechanism(s) from the inactive to the active stage of duodenal ulcer disease (DU) is unclear. It has been shown that hydrogen gas from colonic fermentation provides an important energy source for <i>Helicobacter pylori</i> (Hp) colonization. The lactulose hydrogen breath test (LHBT) is a useful tool to assess the small intestinal and/or colon fermentation. This study examines the association(s) between the status of gastroduodenal disease and the result of a lactulose hydrogen breath test (LHBT). Materials and Methods: We enrolled Hp-positive active duodenal ulcer (aDU) patients, inactive DU (iDU) patients and patients with a positive Hp infection without structural gastroduodenal lesion, i.e., simple gastritis (SG Hp+). The patients with simple gastritis without Hp infection (SG Hp−) served as controls. Histological examinations of the gastric mucosa and lactulose hydrogen breath test (LHBT) were performed. Results: SG Hp+ patients tend to have advanced gastritis (pangastritis or corpus-predominant gastritis) compared with SG Hp− patients (7/29 vs. 0/14, <i>p</i> = 0.08). More iDU patients had advanced gastritis than either the SG Hp+ (7/9 vs. 7/29, <i>p</i> = 0.006) or aDU patients (7/9 vs. 6/24, <i>p</i> = 0.013). In comparison with the aDU patients, the iDU patients were also older (52.1 ± 12.6 vs. 42.2 ± 11.9 years, <i>p</i> = 0.02) and had a lower mean area under the curve value of the LHBT(AUC) (209.1 ± 86.0 vs. 421.9 ± 70.9, <i>p</i> = 0.023). Conclusion: aDU patients with a positive Hp infection have a lower grade of gastric mucosa damage than iDU patients and tend to have a higher level of exhaled hydrogen after LHBT.https://www.mdpi.com/2075-1729/13/1/45<i>Helicobacter pylori</i>lactulose hydrogen breath testduodenal ulcer |
| spellingShingle | Yi-Hsun Chen Sharon Chia-Ju Chen Jiunn-Wei Wang Chiang-Shin Liu Jeng-Yih Wu Deng-Chyang Wu Yu-Chung Su Exhaled Hydrogen after Lactulose Hydrogen Breath Test in Patient with Duodenal Ulcer Disease—A Pilot Study for <i>Helicobacter-pylori</i>-Associated Gastroduodenal Disease Life <i>Helicobacter pylori</i> lactulose hydrogen breath test duodenal ulcer |
| title | Exhaled Hydrogen after Lactulose Hydrogen Breath Test in Patient with Duodenal Ulcer Disease—A Pilot Study for <i>Helicobacter-pylori</i>-Associated Gastroduodenal Disease |
| title_full | Exhaled Hydrogen after Lactulose Hydrogen Breath Test in Patient with Duodenal Ulcer Disease—A Pilot Study for <i>Helicobacter-pylori</i>-Associated Gastroduodenal Disease |
| title_fullStr | Exhaled Hydrogen after Lactulose Hydrogen Breath Test in Patient with Duodenal Ulcer Disease—A Pilot Study for <i>Helicobacter-pylori</i>-Associated Gastroduodenal Disease |
| title_full_unstemmed | Exhaled Hydrogen after Lactulose Hydrogen Breath Test in Patient with Duodenal Ulcer Disease—A Pilot Study for <i>Helicobacter-pylori</i>-Associated Gastroduodenal Disease |
| title_short | Exhaled Hydrogen after Lactulose Hydrogen Breath Test in Patient with Duodenal Ulcer Disease—A Pilot Study for <i>Helicobacter-pylori</i>-Associated Gastroduodenal Disease |
| title_sort | exhaled hydrogen after lactulose hydrogen breath test in patient with duodenal ulcer disease a pilot study for i helicobacter pylori i associated gastroduodenal disease |
| topic | <i>Helicobacter pylori</i> lactulose hydrogen breath test duodenal ulcer |
| url | https://www.mdpi.com/2075-1729/13/1/45 |
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