Acute diesel exhaust exposure and postural stability: a controlled crossover experiment
Abstract Recent epidemiological evidence connects ambient air pollutants to adverse neurobehavioural effects in adults. In animal models, subchronic controlled exposures to diesel exhaust (DE) have also showed evidence of neuroinflammation. Evidence suggests that DE not only affects outcomes commonl...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-01-01
|
| Series: | Journal of Occupational Medicine and Toxicology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12995-017-0182-5 |
| _version_ | 1811262381013073920 |
|---|---|
| author | Jason Curran Rachel Cliff Nadine Sinnen Michael Koehle Chris Carlsten |
| author_facet | Jason Curran Rachel Cliff Nadine Sinnen Michael Koehle Chris Carlsten |
| author_sort | Jason Curran |
| collection | DOAJ |
| description | Abstract Recent epidemiological evidence connects ambient air pollutants to adverse neurobehavioural effects in adults. In animal models, subchronic controlled exposures to diesel exhaust (DE) have also showed evidence of neuroinflammation. Evidence suggests that DE not only affects outcomes commonly associated with cognitive dysfunction, but also balance impairment. We conducted a controlled human exposure experiment with 28 healthy subjects (average age = 28 years (SD = 7.1; range = 21–49); and 40% female) who were exposed to two conditions, filtered air (FA) and DE (300 μg PM2.5/m3) for 120 min, in a double-blinded crossover study with randomized exposures separated by four weeks. Postural stability was assessed by the Balance Error Scoring System (BESS), a brief, easily-administered test of static balance. The BESS consists of a sequence of three stances performed on two surfaces. With hands on hips and eyes closed, each stance is held for 20 s. “Error” points are awarded for deviations from those stances. Pre- and immediately post-exposure BESS “error” point totals were calculated and the difference between the two timepoints were compared for each of the two exposure conditions. A mixed effect model assessed the significance of the association. While our data demonstrates a trend of reduced postural stability in response to exposure to DE, exposure was not significantly associated with BESS value. This is the first study to investigate changes in postural stability as a result of exposure to DE in human subjects. |
| first_indexed | 2024-04-12T19:24:25Z |
| format | Article |
| id | doaj.art-d2a2539081164555886261cf83e1c91f |
| institution | Directory Open Access Journal |
| issn | 1745-6673 |
| language | English |
| last_indexed | 2024-04-12T19:24:25Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Occupational Medicine and Toxicology |
| spelling | doaj.art-d2a2539081164555886261cf83e1c91f2022-12-22T03:19:31ZengBMCJournal of Occupational Medicine and Toxicology1745-66732018-01-011311610.1186/s12995-017-0182-5Acute diesel exhaust exposure and postural stability: a controlled crossover experimentJason Curran0Rachel Cliff1Nadine Sinnen2Michael Koehle3Chris Carlsten4School of Population and Public Health, Faculty of Medicine, University of British ColumbiaSchool of Population and Public Health, Faculty of Medicine, University of British ColumbiaCopeman Healthcare CentreSchool of Kinesiology, University of British ColumbiaSchool of Population and Public Health, Faculty of Medicine, University of British ColumbiaAbstract Recent epidemiological evidence connects ambient air pollutants to adverse neurobehavioural effects in adults. In animal models, subchronic controlled exposures to diesel exhaust (DE) have also showed evidence of neuroinflammation. Evidence suggests that DE not only affects outcomes commonly associated with cognitive dysfunction, but also balance impairment. We conducted a controlled human exposure experiment with 28 healthy subjects (average age = 28 years (SD = 7.1; range = 21–49); and 40% female) who were exposed to two conditions, filtered air (FA) and DE (300 μg PM2.5/m3) for 120 min, in a double-blinded crossover study with randomized exposures separated by four weeks. Postural stability was assessed by the Balance Error Scoring System (BESS), a brief, easily-administered test of static balance. The BESS consists of a sequence of three stances performed on two surfaces. With hands on hips and eyes closed, each stance is held for 20 s. “Error” points are awarded for deviations from those stances. Pre- and immediately post-exposure BESS “error” point totals were calculated and the difference between the two timepoints were compared for each of the two exposure conditions. A mixed effect model assessed the significance of the association. While our data demonstrates a trend of reduced postural stability in response to exposure to DE, exposure was not significantly associated with BESS value. This is the first study to investigate changes in postural stability as a result of exposure to DE in human subjects.http://link.springer.com/article/10.1186/s12995-017-0182-5Air pollutionTrafficDiesel exhaustExposureBalancePostural stability |
| spellingShingle | Jason Curran Rachel Cliff Nadine Sinnen Michael Koehle Chris Carlsten Acute diesel exhaust exposure and postural stability: a controlled crossover experiment Journal of Occupational Medicine and Toxicology Air pollution Traffic Diesel exhaust Exposure Balance Postural stability |
| title | Acute diesel exhaust exposure and postural stability: a controlled crossover experiment |
| title_full | Acute diesel exhaust exposure and postural stability: a controlled crossover experiment |
| title_fullStr | Acute diesel exhaust exposure and postural stability: a controlled crossover experiment |
| title_full_unstemmed | Acute diesel exhaust exposure and postural stability: a controlled crossover experiment |
| title_short | Acute diesel exhaust exposure and postural stability: a controlled crossover experiment |
| title_sort | acute diesel exhaust exposure and postural stability a controlled crossover experiment |
| topic | Air pollution Traffic Diesel exhaust Exposure Balance Postural stability |
| url | http://link.springer.com/article/10.1186/s12995-017-0182-5 |
| work_keys_str_mv | AT jasoncurran acutedieselexhaustexposureandposturalstabilityacontrolledcrossoverexperiment AT rachelcliff acutedieselexhaustexposureandposturalstabilityacontrolledcrossoverexperiment AT nadinesinnen acutedieselexhaustexposureandposturalstabilityacontrolledcrossoverexperiment AT michaelkoehle acutedieselexhaustexposureandposturalstabilityacontrolledcrossoverexperiment AT chriscarlsten acutedieselexhaustexposureandposturalstabilityacontrolledcrossoverexperiment |