Blockers of Skeletal Muscle Na<sub>v</sub>1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back

Blockers of Skeletal Muscle Na<sub>v</sub>1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back

The voltage-gated sodium channels represent an important target for drug discovery since a large number of physiological processes are regulated by these channels. In several excitability disorders, including epilepsy, cardiac arrhythmias, chronic pain, and non-dystrophic myotonia, blockers of volta...

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Bibliographic Details
Main Authors: Michela De Bellis, Brigida Boccanegra, Alessandro Giovanni Cerchiara, Paola Imbrici, Annamaria De Luca
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
sodium channel
skeletal muscle
myotonia
mexiletine
SAR
Online Access:https://www.mdpi.com/1422-0067/24/1/857

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