Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features
Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely prescribed in patients with diabetic polyneuropathy due to its positive effects on nerve conduction and alleviatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/1/18 |
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| author | Umberto Capece Simona Moffa Ilaria Improta Gianfranco Di Giuseppe Enrico Celestino Nista Chiara M. A. Cefalo Francesca Cinti Alfredo Pontecorvi Antonio Gasbarrini Andrea Giaccari Teresa Mezza |
| author_facet | Umberto Capece Simona Moffa Ilaria Improta Gianfranco Di Giuseppe Enrico Celestino Nista Chiara M. A. Cefalo Francesca Cinti Alfredo Pontecorvi Antonio Gasbarrini Andrea Giaccari Teresa Mezza |
| author_sort | Umberto Capece |
| collection | DOAJ |
| description | Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely prescribed in patients with diabetic polyneuropathy due to its positive effects on nerve conduction and alleviation of symptoms. It is, moreover, also prescribed in other insulin resistance conditions such as metabolic syndrome (SM), polycystic ovary syndrome (PCOS) and obesity. However, several cases of Insulin Autoimmune Syndrome (IAS) have been reported in subjects taking ALA. The aim of the present review is to describe the main chemical and biological functions of ALA in glucose metabolism, focusing on its antioxidant activity, its role in modulating insulin sensitivity and secretion and in symptomatic peripheral diabetic polyneuropathy. We also provide a potential explanation for increased risk for the development of IAS. |
| first_indexed | 2024-03-09T09:44:06Z |
| format | Article |
| id | doaj.art-d2a334b4ac4b46678d941197471c9ef0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T09:44:06Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d2a334b4ac4b46678d941197471c9ef02023-12-02T00:45:27ZengMDPI AGNutrients2072-66432022-12-011511810.3390/nu15010018Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic FeaturesUmberto Capece0Simona Moffa1Ilaria Improta2Gianfranco Di Giuseppe3Enrico Celestino Nista4Chiara M. A. Cefalo5Francesca Cinti6Alfredo Pontecorvi7Antonio Gasbarrini8Andrea Giaccari9Teresa Mezza10Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyEndocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyEndocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyEndocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyEndocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyEndocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyEndocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyEndocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyAlpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely prescribed in patients with diabetic polyneuropathy due to its positive effects on nerve conduction and alleviation of symptoms. It is, moreover, also prescribed in other insulin resistance conditions such as metabolic syndrome (SM), polycystic ovary syndrome (PCOS) and obesity. However, several cases of Insulin Autoimmune Syndrome (IAS) have been reported in subjects taking ALA. The aim of the present review is to describe the main chemical and biological functions of ALA in glucose metabolism, focusing on its antioxidant activity, its role in modulating insulin sensitivity and secretion and in symptomatic peripheral diabetic polyneuropathy. We also provide a potential explanation for increased risk for the development of IAS.https://www.mdpi.com/2072-6643/15/1/18alpha-lipoicglucose metabolismdiabetes preventioncomplications |
| spellingShingle | Umberto Capece Simona Moffa Ilaria Improta Gianfranco Di Giuseppe Enrico Celestino Nista Chiara M. A. Cefalo Francesca Cinti Alfredo Pontecorvi Antonio Gasbarrini Andrea Giaccari Teresa Mezza Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features Nutrients alpha-lipoic glucose metabolism diabetes prevention complications |
| title | Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features |
| title_full | Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features |
| title_fullStr | Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features |
| title_full_unstemmed | Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features |
| title_short | Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features |
| title_sort | alpha lipoic acid and glucose metabolism a comprehensive update on biochemical and therapeutic features |
| topic | alpha-lipoic glucose metabolism diabetes prevention complications |
| url | https://www.mdpi.com/2072-6643/15/1/18 |
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