Short Term Efficacy and Safety of Insulin Glargine in Type 2 Diabetes Inadequately Controlled with Single or Two Oral Agents: A Prospective, Open Label Study
Introduction: Basal insulin is among the second line treatment options for Type 2 Diabetes Mellitus (T2DM). Efficacy and safety of basal insulin in patients of T2DM, uncontrolled with Oral Antidiabetic Agents (OAAs) remains understudied in the Indian setting. Aim: To assess the efficacy and saf...
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/10214/27649_CE(EK)_F(RK)_PF1(RB_SS)_PFA(P_RB).pdf |
| _version_ | 1818096893125722112 |
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| author | Ajay Aggarwal Roopak Wadhwa |
| author_facet | Ajay Aggarwal Roopak Wadhwa |
| author_sort | Ajay Aggarwal |
| collection | DOAJ |
| description | Introduction: Basal insulin is among the second line treatment
options for Type 2 Diabetes Mellitus (T2DM). Efficacy and safety
of basal insulin in patients of T2DM, uncontrolled with Oral
Antidiabetic Agents (OAAs) remains understudied in the Indian
setting.
Aim: To assess the efficacy and safety of insulin glargine in
patients with T2DM who have uncontrolled glycaemic levels
despite single or two OAAs therapy.
Materials and Methods: In this prospective, open label study,
T2DM patients above 40 years of age, having inadequate
glycaemic control [Glycosylated Haemoglobin (HbA1c) above
8% and/or fasting glucose level of 140 mg/dl and above]
with single or two OAAs over three consecutive months were
included. Dosing of insulin glargine was adjusted as per Fasting
Blood Glucose (FBG) and Post Prandial Blood Glucose (PPBG)
levels. Patients were followed for 12 weeks and data was
analysed by comparing 12th week findings to baseline values.
Results: In 40 cases included in final analysis, mean age was
56.35 ± 6.77 years, 52.5% were females and mean body mass
index was 26.96 ± 4.59 kg/m2
. Compared to baseline, significant
reduction in HbA1c, FBG and PPBG blood glucose (all p<0.05)
was seen. HbA1c goal of < 7% was achieved in 37.5% cases.
Systolic (p>0.05) and diastolic (p<0.05) blood pressures reduced
at 12 weeks as compared to baseline. Increase in weight was
modest with mean increase of 1.06 kg (p>0.05). Overall, 14
symptomatic hypoglycaemia events were observed with none
being severe.
Conclusion: Short term administration of insulin glargine is
effective in reducing glycaemia and is safe with lower rates of
severe hypoglycaemia. It can be considered in patients with
uncontrolled T2DM on mono- or two- OAAs treatment. |
| first_indexed | 2024-12-10T23:11:51Z |
| format | Article |
| id | doaj.art-d2a3691620e84acab1064a59f189e71a |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-10T23:11:51Z |
| publishDate | 2017-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-d2a3691620e84acab1064a59f189e71a2022-12-22T01:29:55ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-07-01117OC21OC2410.7860/JCDR/2017/27649.10214Short Term Efficacy and Safety of Insulin Glargine in Type 2 Diabetes Inadequately Controlled with Single or Two Oral Agents: A Prospective, Open Label StudyAjay Aggarwal0Roopak Wadhwa1Senior Consultant, Department of Endocrinology, Fortis Hospital, Shalimar Bagh, New Delhi, India. Consultant, Department of Endocrinology, Fortis Hospital, Shalimar Bagh, New Delhi, India.Introduction: Basal insulin is among the second line treatment options for Type 2 Diabetes Mellitus (T2DM). Efficacy and safety of basal insulin in patients of T2DM, uncontrolled with Oral Antidiabetic Agents (OAAs) remains understudied in the Indian setting. Aim: To assess the efficacy and safety of insulin glargine in patients with T2DM who have uncontrolled glycaemic levels despite single or two OAAs therapy. Materials and Methods: In this prospective, open label study, T2DM patients above 40 years of age, having inadequate glycaemic control [Glycosylated Haemoglobin (HbA1c) above 8% and/or fasting glucose level of 140 mg/dl and above] with single or two OAAs over three consecutive months were included. Dosing of insulin glargine was adjusted as per Fasting Blood Glucose (FBG) and Post Prandial Blood Glucose (PPBG) levels. Patients were followed for 12 weeks and data was analysed by comparing 12th week findings to baseline values. Results: In 40 cases included in final analysis, mean age was 56.35 ± 6.77 years, 52.5% were females and mean body mass index was 26.96 ± 4.59 kg/m2 . Compared to baseline, significant reduction in HbA1c, FBG and PPBG blood glucose (all p<0.05) was seen. HbA1c goal of < 7% was achieved in 37.5% cases. Systolic (p>0.05) and diastolic (p<0.05) blood pressures reduced at 12 weeks as compared to baseline. Increase in weight was modest with mean increase of 1.06 kg (p>0.05). Overall, 14 symptomatic hypoglycaemia events were observed with none being severe. Conclusion: Short term administration of insulin glargine is effective in reducing glycaemia and is safe with lower rates of severe hypoglycaemia. It can be considered in patients with uncontrolled T2DM on mono- or two- OAAs treatment.https://jcdr.net/articles/PDF/10214/27649_CE(EK)_F(RK)_PF1(RB_SS)_PFA(P_RB).pdfbasal insulinglycaemiahypoglycaemiauncontrolled diabetes |
| spellingShingle | Ajay Aggarwal Roopak Wadhwa Short Term Efficacy and Safety of Insulin Glargine in Type 2 Diabetes Inadequately Controlled with Single or Two Oral Agents: A Prospective, Open Label Study Journal of Clinical and Diagnostic Research basal insulin glycaemia hypoglycaemia uncontrolled diabetes |
| title | Short Term Efficacy and Safety of Insulin Glargine in Type 2 Diabetes Inadequately Controlled with Single or Two Oral Agents: A Prospective, Open Label Study |
| title_full | Short Term Efficacy and Safety of Insulin Glargine in Type 2 Diabetes Inadequately Controlled with Single or Two Oral Agents: A Prospective, Open Label Study |
| title_fullStr | Short Term Efficacy and Safety of Insulin Glargine in Type 2 Diabetes Inadequately Controlled with Single or Two Oral Agents: A Prospective, Open Label Study |
| title_full_unstemmed | Short Term Efficacy and Safety of Insulin Glargine in Type 2 Diabetes Inadequately Controlled with Single or Two Oral Agents: A Prospective, Open Label Study |
| title_short | Short Term Efficacy and Safety of Insulin Glargine in Type 2 Diabetes Inadequately Controlled with Single or Two Oral Agents: A Prospective, Open Label Study |
| title_sort | short term efficacy and safety of insulin glargine in type 2 diabetes inadequately controlled with single or two oral agents a prospective open label study |
| topic | basal insulin glycaemia hypoglycaemia uncontrolled diabetes |
| url | https://jcdr.net/articles/PDF/10214/27649_CE(EK)_F(RK)_PF1(RB_SS)_PFA(P_RB).pdf |
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