Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese Female
Acanthosis nigricans (AN) is a dermatopathy associated with insulin-resistance, drugs, endocrine disorders, chromosomal abnormalities (benign AN), and neoplasia (malignant AN). Malignant AN (MAN) is a rare paraneoplastic skin syndrome most commonly associated with gastric adenocarcinoma and other in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-02-01
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| Series: | Case Reports in Dermatology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/456652 |
| _version_ | 1818522548655095808 |
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| author | Jacqueline Deen Thomas Moloney David Burdon-Jones |
| author_facet | Jacqueline Deen Thomas Moloney David Burdon-Jones |
| author_sort | Jacqueline Deen |
| collection | DOAJ |
| description | Acanthosis nigricans (AN) is a dermatopathy associated with insulin-resistance, drugs, endocrine disorders, chromosomal abnormalities (benign AN), and neoplasia (malignant AN). Malignant AN (MAN) is a rare paraneoplastic skin syndrome most commonly associated with gastric adenocarcinoma and other intra-abdominal malignancies. We report the case of a 28-year-old female with AN associated with obesity, insulin resistance, and endometrial adenocarcinoma. Although rare, MAN is often an initial sign of malignancy and must trigger extensive investigation, particularly in patients with sudden development of possibly paraneoplastic dermatoses or in patients diagnosed with benign AN with any atypical features. |
| first_indexed | 2024-12-11T05:34:46Z |
| format | Article |
| id | doaj.art-d2a68f14bfd34f378219dcbbaecfde70 |
| institution | Directory Open Access Journal |
| issn | 1662-6567 |
| language | English |
| last_indexed | 2024-12-11T05:34:46Z |
| publishDate | 2017-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Dermatology |
| spelling | doaj.art-d2a68f14bfd34f378219dcbbaecfde702022-12-22T01:19:19ZengKarger PublishersCase Reports in Dermatology1662-65672017-02-0191303710.1159/000456652456652Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese FemaleJacqueline DeenThomas MoloneyDavid Burdon-JonesAcanthosis nigricans (AN) is a dermatopathy associated with insulin-resistance, drugs, endocrine disorders, chromosomal abnormalities (benign AN), and neoplasia (malignant AN). Malignant AN (MAN) is a rare paraneoplastic skin syndrome most commonly associated with gastric adenocarcinoma and other intra-abdominal malignancies. We report the case of a 28-year-old female with AN associated with obesity, insulin resistance, and endometrial adenocarcinoma. Although rare, MAN is often an initial sign of malignancy and must trigger extensive investigation, particularly in patients with sudden development of possibly paraneoplastic dermatoses or in patients diagnosed with benign AN with any atypical features.http://www.karger.com/Article/FullText/456652Malignant acanthosis nigricansBenign acanthosis nigricansEndometrial adenocarcinoma |
| spellingShingle | Jacqueline Deen Thomas Moloney David Burdon-Jones Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese Female Case Reports in Dermatology Malignant acanthosis nigricans Benign acanthosis nigricans Endometrial adenocarcinoma |
| title | Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese Female |
| title_full | Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese Female |
| title_fullStr | Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese Female |
| title_full_unstemmed | Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese Female |
| title_short | Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese Female |
| title_sort | severe malignant acanthosis nigricans associated with adenocarcinoma of the endometrium in a young obese female |
| topic | Malignant acanthosis nigricans Benign acanthosis nigricans Endometrial adenocarcinoma |
| url | http://www.karger.com/Article/FullText/456652 |
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