Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP
Abstract The combination of KRAS G12C inhibitors with EGFR inhibitors has reproducibly been shown to be beneficial. Here, we identify another benefit of this combination: it effectively inhibits both wild-type and mutant RAS. We believe that targeting both mutant and wild-type RAS helps explain why...
| Glavni autori: | , , , , , |
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| Format: | Članak |
| Jezik: | English |
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Nature Portfolio
2022-11-01
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| Serija: | npj Precision Oncology |
| Online pristup: | https://doi.org/10.1038/s41698-022-00329-w |
| _version_ | 1827610083549249536 |
|---|---|
| author | Thomas McFall Michael Trogdon Anita C. Guizar John F. Langenheim Laura Sisk-Hackworth Edward C. Stites |
| author_facet | Thomas McFall Michael Trogdon Anita C. Guizar John F. Langenheim Laura Sisk-Hackworth Edward C. Stites |
| author_sort | Thomas McFall |
| collection | DOAJ |
| description | Abstract The combination of KRAS G12C inhibitors with EGFR inhibitors has reproducibly been shown to be beneficial. Here, we identify another benefit of this combination: it effectively inhibits both wild-type and mutant RAS. We believe that targeting both mutant and wild-type RAS helps explain why this combination of inhibitors is effective. |
| first_indexed | 2024-03-09T07:43:40Z |
| format | Article |
| id | doaj.art-d2a834aeeb10413aae877a20897f77b6 |
| institution | Directory Open Access Journal |
| issn | 2397-768X |
| language | English |
| last_indexed | 2024-03-09T07:43:40Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Precision Oncology |
| spelling | doaj.art-d2a834aeeb10413aae877a20897f77b62023-12-03T04:15:14ZengNature Portfolionpj Precision Oncology2397-768X2022-11-01611710.1038/s41698-022-00329-wCo-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTPThomas McFall0Michael Trogdon1Anita C. Guizar2John F. Langenheim3Laura Sisk-Hackworth4Edward C. Stites5Department of Biochemistry and MCW Cancer Center, Medical College of WisconsinIntegrative Biology Laboratory, Salk Institute for Biological StudiesDepartment of Biochemistry and MCW Cancer Center, Medical College of WisconsinDepartment of Pathology, Medical College of WisconsinIntegrative Biology Laboratory, Salk Institute for Biological StudiesIntegrative Biology Laboratory, Salk Institute for Biological StudiesAbstract The combination of KRAS G12C inhibitors with EGFR inhibitors has reproducibly been shown to be beneficial. Here, we identify another benefit of this combination: it effectively inhibits both wild-type and mutant RAS. We believe that targeting both mutant and wild-type RAS helps explain why this combination of inhibitors is effective.https://doi.org/10.1038/s41698-022-00329-w |
| spellingShingle | Thomas McFall Michael Trogdon Anita C. Guizar John F. Langenheim Laura Sisk-Hackworth Edward C. Stites Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP npj Precision Oncology |
| title | Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP |
| title_full | Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP |
| title_fullStr | Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP |
| title_full_unstemmed | Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP |
| title_short | Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP |
| title_sort | co targeting kras g12c and egfr reduces both mutant and wild type ras gtp |
| url | https://doi.org/10.1038/s41698-022-00329-w |
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