Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity
Abstract Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of amino acid metabolic strategies in antitumor therapy. Tremendous efforts have been made to develop amino acid...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-023-02845-4 |
| _version_ | 1797636645773639680 |
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| author | Yue Zheng Yiran Yao Tongxin Ge Shengfang Ge Renbing Jia Xin Song Ai Zhuang |
| author_facet | Yue Zheng Yiran Yao Tongxin Ge Shengfang Ge Renbing Jia Xin Song Ai Zhuang |
| author_sort | Yue Zheng |
| collection | DOAJ |
| description | Abstract Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of amino acid metabolic strategies in antitumor therapy. Tremendous efforts have been made to develop amino acid metabolic node interventions such as amino acid antagonists and targeting amino acid transporters, key enzymes of amino acid metabolism, and common downstream pathways of amino acid metabolism. In addition to playing an essential role in sustaining tumor growth, new technologies and studies has revealed amino acid metabolic reprograming to have wide implications in the regulation of antitumor immune responses. Specifically, extensive crosstalk between amino acid metabolism and T cell immunity has been reported. Tumor cells can inhibit T cell immunity by depleting amino acids in the microenvironment through nutrient competition, and toxic metabolites of amino acids can also inhibit T cell function. In addition, amino acids can interfere with T cells by regulating glucose and lipid metabolism. This crucial crosstalk inspires the exploitation of novel strategies of immunotherapy enhancement and combination, owing to the unprecedented benefits of immunotherapy and the limited population it can benefit. Herein, we review recent findings related to the crosstalk between amino acid metabolism and T cell immunity. We also describe possible approaches to intervene in amino acid metabolic pathways by targeting various signaling nodes. Novel efforts to combine with and unleash potential immunotherapy are also discussed. Hopefully, some strategies that take the lead in the pipeline may soon be used for the common good. |
| first_indexed | 2024-03-11T12:37:01Z |
| format | Article |
| id | doaj.art-d2a8694cb1604e14bd5840b3560c931c |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-03-11T12:37:01Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-d2a8694cb1604e14bd5840b3560c931c2023-11-05T12:32:25ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662023-11-0142112310.1186/s13046-023-02845-4Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunityYue Zheng0Yiran Yao1Tongxin Ge2Shengfang Ge3Renbing Jia4Xin Song5Ai Zhuang6Department of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineAbstract Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of amino acid metabolic strategies in antitumor therapy. Tremendous efforts have been made to develop amino acid metabolic node interventions such as amino acid antagonists and targeting amino acid transporters, key enzymes of amino acid metabolism, and common downstream pathways of amino acid metabolism. In addition to playing an essential role in sustaining tumor growth, new technologies and studies has revealed amino acid metabolic reprograming to have wide implications in the regulation of antitumor immune responses. Specifically, extensive crosstalk between amino acid metabolism and T cell immunity has been reported. Tumor cells can inhibit T cell immunity by depleting amino acids in the microenvironment through nutrient competition, and toxic metabolites of amino acids can also inhibit T cell function. In addition, amino acids can interfere with T cells by regulating glucose and lipid metabolism. This crucial crosstalk inspires the exploitation of novel strategies of immunotherapy enhancement and combination, owing to the unprecedented benefits of immunotherapy and the limited population it can benefit. Herein, we review recent findings related to the crosstalk between amino acid metabolism and T cell immunity. We also describe possible approaches to intervene in amino acid metabolic pathways by targeting various signaling nodes. Novel efforts to combine with and unleash potential immunotherapy are also discussed. Hopefully, some strategies that take the lead in the pipeline may soon be used for the common good.https://doi.org/10.1186/s13046-023-02845-4Amino acidMetabolism reprogrammingTumor microenvironmentT cellImmunotherapy |
| spellingShingle | Yue Zheng Yiran Yao Tongxin Ge Shengfang Ge Renbing Jia Xin Song Ai Zhuang Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity Journal of Experimental & Clinical Cancer Research Amino acid Metabolism reprogramming Tumor microenvironment T cell Immunotherapy |
| title | Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity |
| title_full | Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity |
| title_fullStr | Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity |
| title_full_unstemmed | Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity |
| title_short | Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity |
| title_sort | amino acid metabolism reprogramming shedding new light on t cell anti tumor immunity |
| topic | Amino acid Metabolism reprogramming Tumor microenvironment T cell Immunotherapy |
| url | https://doi.org/10.1186/s13046-023-02845-4 |
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