Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006–2016
Global expansion of antimicrobial drug–resistant Escherichia coli sequence type (ST) 131 is unrivaled among human bacteria. Understanding trends among ST131 clades will help with designing prevention strategies. We screened E. coli from blood samples (n = 1,784) obtained in Calgary, Alberta, Canada,...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2020-12-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/26/12/20-1221_article |
| _version_ | 1811258255561719808 |
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| author | Gisele Peirano Tarah Lynch Yasufumi Matsumara Diego Nobrega Thomas J. Finn Rebekah DeVinney Johann D.D. Pitout |
| author_facet | Gisele Peirano Tarah Lynch Yasufumi Matsumara Diego Nobrega Thomas J. Finn Rebekah DeVinney Johann D.D. Pitout |
| author_sort | Gisele Peirano |
| collection | DOAJ |
| description | Global expansion of antimicrobial drug–resistant Escherichia coli sequence type (ST) 131 is unrivaled among human bacteria. Understanding trends among ST131 clades will help with designing prevention strategies. We screened E. coli from blood samples (n = 1,784) obtained in Calgary, Alberta, Canada, during 2006, 2012, and 2016 by PCR for ST131 and positive samples (n = 344) underwent whole-genome sequencing. The incidence rate per 100,000 residents increased from 4.91 during 2006 to 12.35 during 2012 and 10.12 during 2016. ST131 belonged to clades A (10%), B (9%), and C (81%). Clades C1-nonM27 and B were common during 2006, and C2 containing blaCTX-M-15, C1-M27 containing blaCTX-M-27, and A were responsible for the increase of ST131 during 2012 and 2016. C2 was the most antimicrobial drug–resistant subclade and increased exponentially over time. Eradicating ST131, more specifically the C2 subclade, will lead to considerable public health benefits for persons in Calgary. |
| first_indexed | 2024-04-12T18:10:29Z |
| format | Article |
| id | doaj.art-d2a94fae9e034d8089043f2ef905397e |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T18:10:29Z |
| publishDate | 2020-12-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-d2a94fae9e034d8089043f2ef905397e2022-12-22T03:21:50ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592020-12-0126122907291510.3201/eid2612.201221Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006–2016Gisele PeiranoTarah LynchYasufumi MatsumaraDiego NobregaThomas J. FinnRebekah DeVinneyJohann D.D. PitoutGlobal expansion of antimicrobial drug–resistant Escherichia coli sequence type (ST) 131 is unrivaled among human bacteria. Understanding trends among ST131 clades will help with designing prevention strategies. We screened E. coli from blood samples (n = 1,784) obtained in Calgary, Alberta, Canada, during 2006, 2012, and 2016 by PCR for ST131 and positive samples (n = 344) underwent whole-genome sequencing. The incidence rate per 100,000 residents increased from 4.91 during 2006 to 12.35 during 2012 and 10.12 during 2016. ST131 belonged to clades A (10%), B (9%), and C (81%). Clades C1-nonM27 and B were common during 2006, and C2 containing blaCTX-M-15, C1-M27 containing blaCTX-M-27, and A were responsible for the increase of ST131 during 2012 and 2016. C2 was the most antimicrobial drug–resistant subclade and increased exponentially over time. Eradicating ST131, more specifically the C2 subclade, will lead to considerable public health benefits for persons in Calgary.https://wwwnc.cdc.gov/eid/article/26/12/20-1221_articleEscherichia colibacteriabloodstream infectionspopulation surveillancepopulation dynamicstrends |
| spellingShingle | Gisele Peirano Tarah Lynch Yasufumi Matsumara Diego Nobrega Thomas J. Finn Rebekah DeVinney Johann D.D. Pitout Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006–2016 Emerging Infectious Diseases Escherichia coli bacteria bloodstream infections population surveillance population dynamics trends |
| title | Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006–2016 |
| title_full | Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006–2016 |
| title_fullStr | Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006–2016 |
| title_full_unstemmed | Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006–2016 |
| title_short | Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006–2016 |
| title_sort | trends in population dynamics of escherichia coli sequence type 131 calgary alberta canada 2006 2016 |
| topic | Escherichia coli bacteria bloodstream infections population surveillance population dynamics trends |
| url | https://wwwnc.cdc.gov/eid/article/26/12/20-1221_article |
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