The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma
Non-invasive diagnostic biomarkers of equine asthma syndrome (EAS) from blood or urine are sought. The aim of this study was to assess the absorbance of circulating immune complexes (CICs) during the exacerbation, remission, and treatment of an asthma episode and assess the potential usefulness of C...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/4/1001 |
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| author | Malwina Slowikowska Joanna Bajzert Julia Miller Tadeusz Stefaniak Artur Niedzwiedz |
| author_facet | Malwina Slowikowska Joanna Bajzert Julia Miller Tadeusz Stefaniak Artur Niedzwiedz |
| author_sort | Malwina Slowikowska |
| collection | DOAJ |
| description | Non-invasive diagnostic biomarkers of equine asthma syndrome (EAS) from blood or urine are sought. The aim of this study was to assess the absorbance of circulating immune complexes (CICs) during the exacerbation, remission, and treatment of an asthma episode and assess the potential usefulness of CIC levels in the diagnosis and monitoring of the disease. The control group, asthma group, and treated asthma group each contained six horses. Following an initial examination and group classification, the horses were kept in a dusty environment for seven days and then moved to an asthma-friendly environment for three weeks (the treated group received injections of glucocorticoids). Blood was collected at baseline and on the 1st, 2nd, 3rd, 7th, 14th and 30th days. CIC was measured using the modified Haskova method. The time points did not show significant statistical differences. There was a significant decrease in CIC in the treated group, and a significant increase in CIC in the non-treated group on day 30. CIC did not support the EAS diagnosis, although it may help in monitoring patients. To the best of the authors’ knowledge, this is the first study to analyse the dynamics of CIC during environmental challenge, remission, and treatment. |
| first_indexed | 2024-03-10T12:39:04Z |
| format | Article |
| id | doaj.art-d2a96295c9004651a4650b32e8cb6a9e |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T12:39:04Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-d2a96295c9004651a4650b32e8cb6a9e2023-11-21T14:02:47ZengMDPI AGAnimals2076-26152021-04-01114100110.3390/ani11041001The Dynamics of Circulating Immune Complexes in Horses with Severe Equine AsthmaMalwina Slowikowska0Joanna Bajzert1Julia Miller2Tadeusz Stefaniak3Artur Niedzwiedz4Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, PolandDepartment of Immunology, Pathophysiology and Veterinary Preventive Medicine, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, PolandDepartment of Immunology, Pathophysiology and Veterinary Preventive Medicine, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, PolandDepartment of Immunology, Pathophysiology and Veterinary Preventive Medicine, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, PolandDepartment of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, PolandNon-invasive diagnostic biomarkers of equine asthma syndrome (EAS) from blood or urine are sought. The aim of this study was to assess the absorbance of circulating immune complexes (CICs) during the exacerbation, remission, and treatment of an asthma episode and assess the potential usefulness of CIC levels in the diagnosis and monitoring of the disease. The control group, asthma group, and treated asthma group each contained six horses. Following an initial examination and group classification, the horses were kept in a dusty environment for seven days and then moved to an asthma-friendly environment for three weeks (the treated group received injections of glucocorticoids). Blood was collected at baseline and on the 1st, 2nd, 3rd, 7th, 14th and 30th days. CIC was measured using the modified Haskova method. The time points did not show significant statistical differences. There was a significant decrease in CIC in the treated group, and a significant increase in CIC in the non-treated group on day 30. CIC did not support the EAS diagnosis, although it may help in monitoring patients. To the best of the authors’ knowledge, this is the first study to analyse the dynamics of CIC during environmental challenge, remission, and treatment.https://www.mdpi.com/2076-2615/11/4/1001circulating immune complexesequine asthma syndromeheavesrecurrent airway obstructionasthma environmental challenge |
| spellingShingle | Malwina Slowikowska Joanna Bajzert Julia Miller Tadeusz Stefaniak Artur Niedzwiedz The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma Animals circulating immune complexes equine asthma syndrome heaves recurrent airway obstruction asthma environmental challenge |
| title | The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma |
| title_full | The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma |
| title_fullStr | The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma |
| title_full_unstemmed | The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma |
| title_short | The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma |
| title_sort | dynamics of circulating immune complexes in horses with severe equine asthma |
| topic | circulating immune complexes equine asthma syndrome heaves recurrent airway obstruction asthma environmental challenge |
| url | https://www.mdpi.com/2076-2615/11/4/1001 |
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