Sacubitril/Valsartan Improves Left Atrial and Left Atrial Appendage Function in Patients With Atrial Fibrillation and in Pressure Overload-Induced Mice

Sacubitril/Valsartan Improves Left Atrial and Left Atrial Appendage Function in Patients With Atrial Fibrillation and in Pressure Overload-Induced Mice

LCZ696 (sacubitril/valsartan) is an angiotensin receptor-neprilysin inhibitor and has shown beneficial effects in patients with heart failure. However, whether LCZ696 protects against left atrial (LA) and LA appendage (LAA) dysfunction is still unclear. The present study aimed to assess the efficacy...

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Bibliographic Details
Main Authors: Ya Suo, Meng Yuan, Hongmin Li, Yue Zhang, Ying Li, Huaying Fu, Fei Han, Changhui Ma, Yuanyuan Wang, Qiankun Bao, Guangping Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
sacubitril/valsartan
atrial fibrillation
left atrial function
left atrial appendage thrombus
atrial fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01285/full

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