Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil
IntroductionSince the 1990s there has been evidence of the significant role Flumazenil (FLU) has in benzodiazepines (BZD) detoxes. The Verona Detox approach has been developed for high dose BZD and Z-drug detoxification via continuous subcutaneous infusion of FLU, a selective BZD receptor antagonist...
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.857376/full |
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| author | Rebecca Casari Antonio Metastasio Lorenzo Zamboni Lorenzo Zamboni Martino Biasioli Simone Campagnari Fabio Lugoboni |
| author_facet | Rebecca Casari Antonio Metastasio Lorenzo Zamboni Lorenzo Zamboni Martino Biasioli Simone Campagnari Fabio Lugoboni |
| author_sort | Rebecca Casari |
| collection | DOAJ |
| description | IntroductionSince the 1990s there has been evidence of the significant role Flumazenil (FLU) has in benzodiazepines (BZD) detoxes. The Verona Detox approach has been developed for high dose BZD and Z-drug detoxification via continuous subcutaneous infusion of FLU, a selective BZD receptor antagonist acting on the BZD subunit of the GABA-A receptor. Flumazenil is licensed in the United Kingdom and other countries to treat only BZD overdose although numerous studies have demonstrated its effectiveness in rapidly resetting GABA-A receptors, quickly reducing tolerance and dependence from BZD, and providing a safe and rapid detox from benzodiazepines.ObjectiveThe aim of this article is to provide all healthcare professional who are interested in BZD detoxification with an approach and clear practical information on how to administer FLU.MethodIn this article we outline the approach in detail, describing all medical and nursing procedures day by day. This detox treatment is indicated for patients abusing from at least 5 Defined Daily Dose (DDD) of BZDs or Z-drugs. The process lasts 7 days, and is conducted under medical supervision (daily reviews) and continuous nursing (24/7). During this period, 7mg of FLU is administered (1 mg/24) through an elastomeric pump, via continuous subcutaneous infusion.ConclusionTo this day, the largest database of FLU detoxification was published by our group, showing how this treatment is safe, with very little side effects even in patients with significant medical comorbidities. |
| first_indexed | 2024-12-18T10:58:27Z |
| format | Article |
| id | doaj.art-d2acab06673b4263996bcdcf95a5b5a5 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-18T10:58:27Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-d2acab06673b4263996bcdcf95a5b5a52022-12-21T21:10:17ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-03-011310.3389/fpsyt.2022.857376857376Addiction of High Dose of Benzodiazepine: Verona Detox Approach With FlumazenilRebecca Casari0Antonio Metastasio1Lorenzo Zamboni2Lorenzo Zamboni3Martino Biasioli4Simone Campagnari5Fabio Lugoboni6Unit of Addiction Medicine, Department of Internal Medicine, Integrated University Hospital of Verona, Verona, ItalyCamden and Islington NHS Foundation Trust, London, United KingdomUnit of Addiction Medicine, Department of Internal Medicine, Integrated University Hospital of Verona, Verona, ItalyDepartment of Neurosciences, University of Verona, Verona, ItalyUnit of Addiction Medicine, Department of Internal Medicine, Integrated University Hospital of Verona, Verona, ItalyUnit of Addiction Medicine, Department of Internal Medicine, Integrated University Hospital of Verona, Verona, ItalyUnit of Addiction Medicine, Department of Internal Medicine, Integrated University Hospital of Verona, Verona, ItalyIntroductionSince the 1990s there has been evidence of the significant role Flumazenil (FLU) has in benzodiazepines (BZD) detoxes. The Verona Detox approach has been developed for high dose BZD and Z-drug detoxification via continuous subcutaneous infusion of FLU, a selective BZD receptor antagonist acting on the BZD subunit of the GABA-A receptor. Flumazenil is licensed in the United Kingdom and other countries to treat only BZD overdose although numerous studies have demonstrated its effectiveness in rapidly resetting GABA-A receptors, quickly reducing tolerance and dependence from BZD, and providing a safe and rapid detox from benzodiazepines.ObjectiveThe aim of this article is to provide all healthcare professional who are interested in BZD detoxification with an approach and clear practical information on how to administer FLU.MethodIn this article we outline the approach in detail, describing all medical and nursing procedures day by day. This detox treatment is indicated for patients abusing from at least 5 Defined Daily Dose (DDD) of BZDs or Z-drugs. The process lasts 7 days, and is conducted under medical supervision (daily reviews) and continuous nursing (24/7). During this period, 7mg of FLU is administered (1 mg/24) through an elastomeric pump, via continuous subcutaneous infusion.ConclusionTo this day, the largest database of FLU detoxification was published by our group, showing how this treatment is safe, with very little side effects even in patients with significant medical comorbidities.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.857376/fullbenzodiazepineaddictionflumazenildetoxhigh dose |
| spellingShingle | Rebecca Casari Antonio Metastasio Lorenzo Zamboni Lorenzo Zamboni Martino Biasioli Simone Campagnari Fabio Lugoboni Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil Frontiers in Psychiatry benzodiazepine addiction flumazenil detox high dose |
| title | Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil |
| title_full | Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil |
| title_fullStr | Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil |
| title_full_unstemmed | Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil |
| title_short | Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil |
| title_sort | addiction of high dose of benzodiazepine verona detox approach with flumazenil |
| topic | benzodiazepine addiction flumazenil detox high dose |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.857376/full |
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