The Role of miR-29 Family in TGF-β Driven Fibrosis in Glaucomatous Optic Neuropathy

The Role of miR-29 Family in TGF-β Driven Fibrosis in Glaucomatous Optic Neuropathy

Primary open angle glaucoma (POAG), a chronic optic neuropathy, remains the leading cause of irreversible blindness worldwide. It is driven in part by the pro-fibrotic cytokine transforming growth factor beta (TGF-β) and leads to extracellular matrix remodelling at the lamina cribrosa of the optic n...

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Bibliographic Details
Main Authors: Aoife Smyth, Breedge Callaghan, Colin E. Willoughby, Colm O’Brien
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
glaucoma
glaucomatous optic neuropathy
fibrosis
miR-29
extracellular matrix
Online Access:https://www.mdpi.com/1422-0067/23/18/10216

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