Crohn’s disease-associated AIEC inhibiting intestinal epithelial cell-derived exosomal let-7b expression regulates macrophage polarization to exacerbate intestinal fibrosis

Crohn’s disease-associated AIEC inhibiting intestinal epithelial cell-derived exosomal let-7b expression regulates macrophage polarization to exacerbate intestinal fibrosis

ABSTRACTThe interaction between adherent-invasive Escherichia coli (AIEC) and intestinal macrophages is implicated in the pathogenesis of Crohn’s disease (CD). However, its role in intestinal fibrogenesis and the underlying molecular mechanisms are poorly understood. In addition, miRNAs such as let-...

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Bibliographic Details
Main Authors: Yihan Xu, Wenwei Qian, Liangyu Huang, Weiwei Wen, Yi Li, Feilong Guo, Zhenxing Zhu, Zhun Li, Jianfeng Gong, Zeqian Yu, Yan Zhou, Nan Lu, Weiming Zhu, Zhen Guo
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
Crohn’s disease
adherent-invasiveEscherichia coli
macrophage
miRNA
intestinal fibrosis
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2193115

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