History of S. aureus Skin Infection Significantly Associates with History of Eczema Herpeticum in Patients with Atopic Dermatitis
Abstract Introduction Patients with atopic dermatitis (AD) are uniquely susceptible to a number of serious viral skin complications, including eczema herpeticum (EH), caused by herpes simplex virus. This study explored the associations between biomarkers of epithelial barrier dysfunction, type 2 imm...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-08-01
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| Series: | Dermatology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13555-023-00996-y |
| _version_ | 1797669599751176192 |
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| author | Mary C. Moran Alanna Klose Takeshi Yoshida Anna De Benedetto Lynda C. Schneider Peck Y. Ong Eric L. Simpson Donald Y. M. Leung Benjamin L. Miller Christopher L. Seplaki Lisa A. Beck |
| author_facet | Mary C. Moran Alanna Klose Takeshi Yoshida Anna De Benedetto Lynda C. Schneider Peck Y. Ong Eric L. Simpson Donald Y. M. Leung Benjamin L. Miller Christopher L. Seplaki Lisa A. Beck |
| author_sort | Mary C. Moran |
| collection | DOAJ |
| description | Abstract Introduction Patients with atopic dermatitis (AD) are uniquely susceptible to a number of serious viral skin complications, including eczema herpeticum (EH), caused by herpes simplex virus. This study explored the associations between biomarkers of epithelial barrier dysfunction, type 2 immunity, Staphylococcus aureus infection, and S. aureus-specific immunoglobulin responses in a cohort of AD subjects with and without a history of EH (EH+ and EH−, respectively). Methods A total of 112 subjects with AD (56 EH+, 56 EH−), matched by age and AD severity, were selected from a registry of over 3000 AD subjects. Logistic regression was used to test the association between history of S. aureus skin infection and history of EH, while controlling for a number of confounders. Results Compared to those without a history of S. aureus skin infection, subjects with a history of S. aureus skin infection were found to have more than sixfold increased odds of having a history of EH (6.60, 95% confidence interval [CI]: 2.00–21.83), after adjusting for history of other viral skin infections (molluscum contagiosum virus, human papillomavirus), serum total IgE, and IgG against the S. aureus virulence factor SElX. Conclusions These findings indicate an important relationship between S. aureus skin infections and EH. |
| first_indexed | 2024-03-11T20:46:47Z |
| format | Article |
| id | doaj.art-d2aef2693df54f3aabb2350add3a7ef3 |
| institution | Directory Open Access Journal |
| issn | 2193-8210 2190-9172 |
| language | English |
| last_indexed | 2024-03-11T20:46:47Z |
| publishDate | 2023-08-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj.art-d2aef2693df54f3aabb2350add3a7ef32023-10-01T11:06:43ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722023-08-0113102417242910.1007/s13555-023-00996-yHistory of S. aureus Skin Infection Significantly Associates with History of Eczema Herpeticum in Patients with Atopic DermatitisMary C. Moran0Alanna Klose1Takeshi Yoshida2Anna De Benedetto3Lynda C. Schneider4Peck Y. Ong5Eric L. Simpson6Donald Y. M. Leung7Benjamin L. Miller8Christopher L. Seplaki9Lisa A. Beck10Department of Dermatology, University of Rochester Medical CenterDepartment of Dermatology, University of Rochester Medical CenterDepartment of Dermatology, University of Rochester Medical CenterDepartment of Dermatology, University of Rochester Medical CenterDivision of Allergy-Immunology, Department of Pediatrics, Boston Children’s Hospital–Harvard Medical SchoolDivision of Clinical Immunology and Allergy, Children’s Hospital Los Angeles–University of Southern CaliforniaDepartment of Dermatology, Oregon Health and Science UniversityDivision of Allergy-Immunology, Department of Pediatrics, National Jewish Health–University of Colorado School of MedicineDepartment of Dermatology, University of Rochester Medical CenterDepartment of Public Health Sciences, University of Rochester Medical CenterDepartment of Dermatology, University of Rochester Medical CenterAbstract Introduction Patients with atopic dermatitis (AD) are uniquely susceptible to a number of serious viral skin complications, including eczema herpeticum (EH), caused by herpes simplex virus. This study explored the associations between biomarkers of epithelial barrier dysfunction, type 2 immunity, Staphylococcus aureus infection, and S. aureus-specific immunoglobulin responses in a cohort of AD subjects with and without a history of EH (EH+ and EH−, respectively). Methods A total of 112 subjects with AD (56 EH+, 56 EH−), matched by age and AD severity, were selected from a registry of over 3000 AD subjects. Logistic regression was used to test the association between history of S. aureus skin infection and history of EH, while controlling for a number of confounders. Results Compared to those without a history of S. aureus skin infection, subjects with a history of S. aureus skin infection were found to have more than sixfold increased odds of having a history of EH (6.60, 95% confidence interval [CI]: 2.00–21.83), after adjusting for history of other viral skin infections (molluscum contagiosum virus, human papillomavirus), serum total IgE, and IgG against the S. aureus virulence factor SElX. Conclusions These findings indicate an important relationship between S. aureus skin infections and EH.https://doi.org/10.1007/s13555-023-00996-yAtopic dermatitisS. aureusEczema herpeticumViral skin infectionsImmunoglobulins |
| spellingShingle | Mary C. Moran Alanna Klose Takeshi Yoshida Anna De Benedetto Lynda C. Schneider Peck Y. Ong Eric L. Simpson Donald Y. M. Leung Benjamin L. Miller Christopher L. Seplaki Lisa A. Beck History of S. aureus Skin Infection Significantly Associates with History of Eczema Herpeticum in Patients with Atopic Dermatitis Dermatology and Therapy Atopic dermatitis S. aureus Eczema herpeticum Viral skin infections Immunoglobulins |
| title | History of S. aureus Skin Infection Significantly Associates with History of Eczema Herpeticum in Patients with Atopic Dermatitis |
| title_full | History of S. aureus Skin Infection Significantly Associates with History of Eczema Herpeticum in Patients with Atopic Dermatitis |
| title_fullStr | History of S. aureus Skin Infection Significantly Associates with History of Eczema Herpeticum in Patients with Atopic Dermatitis |
| title_full_unstemmed | History of S. aureus Skin Infection Significantly Associates with History of Eczema Herpeticum in Patients with Atopic Dermatitis |
| title_short | History of S. aureus Skin Infection Significantly Associates with History of Eczema Herpeticum in Patients with Atopic Dermatitis |
| title_sort | history of s aureus skin infection significantly associates with history of eczema herpeticum in patients with atopic dermatitis |
| topic | Atopic dermatitis S. aureus Eczema herpeticum Viral skin infections Immunoglobulins |
| url | https://doi.org/10.1007/s13555-023-00996-y |
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