The environment and female reproduction: Potential mechanism of cadmium poisoning to the growth and development of ovarian follicle
Cadmium (Cd) is ubiquitous in our environment and can easily bioaccumulate into the organism after passage through the respiratory and digestive tracts. Long-term exposure to Cd can result in the significant bioaccumulation in organism because of its long biological high-life (10–30 years), which ex...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322008697 |
| _version_ | 1811271567256059904 |
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| author | Jingwen Qu Qiang Wang Xiaomei Sun Yongjun Li |
| author_facet | Jingwen Qu Qiang Wang Xiaomei Sun Yongjun Li |
| author_sort | Jingwen Qu |
| collection | DOAJ |
| description | Cadmium (Cd) is ubiquitous in our environment and can easily bioaccumulate into the organism after passage through the respiratory and digestive tracts. Long-term exposure to Cd can result in the significant bioaccumulation in organism because of its long biological high-life (10–30 years), which exerts irreversible damages on the health of animals and humans. Although there are increased evidence of impeding the normal function of female reproduction resulted from Cd exposure, the mechanism of the negative action of Cd on the growth and development of ovarian follicle remains enigmatic. Thus, the purpose of the presented study is to summarize available literature which describing Cd-related toxicity involved in the adverse effects on the growth and development of the ovarian follicle. In conclusion, it is suggested that Cd causes damage to the folliculogenesis of mammalians, which results in the decline in the number and quality of ovulated oocytes and the failure in the fertilization. The mechanism behinds that may be linked to the interference to the production of reproductive hormones and the augment of reactive oxygen species (ROS). Furthermore, the enhanced ROS, in turn, impairs various molecules including proteins, lipids and DNA, as well as the balance of the antioxidant defense system, mitochondrial homeostasis, endoplasmic reticulum, autophagy and epigenetic modification. This review is expected to elaborate the toxic mechanism of Cd exposure to the growth and development of ovarian follicles and provide essential remediation strategies to alleviate the damage of Cd to female reproductive health. |
| first_indexed | 2024-04-12T22:22:15Z |
| format | Article |
| id | doaj.art-d2af1287cce74b20b84c73a9d4d6e2fb |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-12T22:22:15Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-d2af1287cce74b20b84c73a9d4d6e2fb2022-12-22T03:14:19ZengElsevierEcotoxicology and Environmental Safety0147-65132022-10-01244114029The environment and female reproduction: Potential mechanism of cadmium poisoning to the growth and development of ovarian follicleJingwen Qu0Qiang Wang1Xiaomei Sun2Yongjun Li3Key Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China; Department of Animal Science, University of Vermont, Burlington, VT 05405, USAKey Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaKey Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaKey Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China; Corresponding author.Cadmium (Cd) is ubiquitous in our environment and can easily bioaccumulate into the organism after passage through the respiratory and digestive tracts. Long-term exposure to Cd can result in the significant bioaccumulation in organism because of its long biological high-life (10–30 years), which exerts irreversible damages on the health of animals and humans. Although there are increased evidence of impeding the normal function of female reproduction resulted from Cd exposure, the mechanism of the negative action of Cd on the growth and development of ovarian follicle remains enigmatic. Thus, the purpose of the presented study is to summarize available literature which describing Cd-related toxicity involved in the adverse effects on the growth and development of the ovarian follicle. In conclusion, it is suggested that Cd causes damage to the folliculogenesis of mammalians, which results in the decline in the number and quality of ovulated oocytes and the failure in the fertilization. The mechanism behinds that may be linked to the interference to the production of reproductive hormones and the augment of reactive oxygen species (ROS). Furthermore, the enhanced ROS, in turn, impairs various molecules including proteins, lipids and DNA, as well as the balance of the antioxidant defense system, mitochondrial homeostasis, endoplasmic reticulum, autophagy and epigenetic modification. This review is expected to elaborate the toxic mechanism of Cd exposure to the growth and development of ovarian follicles and provide essential remediation strategies to alleviate the damage of Cd to female reproductive health.http://www.sciencedirect.com/science/article/pii/S0147651322008697CadmiumFolliculogenesisOxidative stressMitochondrial homeostasis disruptEndoplasmic reticulum stressAutophagy |
| spellingShingle | Jingwen Qu Qiang Wang Xiaomei Sun Yongjun Li The environment and female reproduction: Potential mechanism of cadmium poisoning to the growth and development of ovarian follicle Ecotoxicology and Environmental Safety Cadmium Folliculogenesis Oxidative stress Mitochondrial homeostasis disrupt Endoplasmic reticulum stress Autophagy |
| title | The environment and female reproduction: Potential mechanism of cadmium poisoning to the growth and development of ovarian follicle |
| title_full | The environment and female reproduction: Potential mechanism of cadmium poisoning to the growth and development of ovarian follicle |
| title_fullStr | The environment and female reproduction: Potential mechanism of cadmium poisoning to the growth and development of ovarian follicle |
| title_full_unstemmed | The environment and female reproduction: Potential mechanism of cadmium poisoning to the growth and development of ovarian follicle |
| title_short | The environment and female reproduction: Potential mechanism of cadmium poisoning to the growth and development of ovarian follicle |
| title_sort | environment and female reproduction potential mechanism of cadmium poisoning to the growth and development of ovarian follicle |
| topic | Cadmium Folliculogenesis Oxidative stress Mitochondrial homeostasis disrupt Endoplasmic reticulum stress Autophagy |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322008697 |
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