A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke
Abstract Prompt recognition and treatment for thrombotic thrombocytopenic purpura (TTP) are critical to prevent the irreversible manifestations of this rare and quickly fatal hematologic disorder. Untreated TTP is typically a rapid‐onset disease with mortality exceeding 90% within days in the absenc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-10-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.4850 |
| _version_ | 1830417315722690560 |
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| author | Mark E. Pepin Eyad Saca Soo Y. Kwon Jori May |
| author_facet | Mark E. Pepin Eyad Saca Soo Y. Kwon Jori May |
| author_sort | Mark E. Pepin |
| collection | DOAJ |
| description | Abstract Prompt recognition and treatment for thrombotic thrombocytopenic purpura (TTP) are critical to prevent the irreversible manifestations of this rare and quickly fatal hematologic disorder. Untreated TTP is typically a rapid‐onset disease with mortality exceeding 90% within days in the absence of appropriate treatment. In the current report, we describe a case of immune‐mediated TTP (iTTP) in a 62‐year‐old man manifesting as longstanding thrombocytopenia, recurrent cardioembolic strokes, and valvular thrombogenesis over a period of 3 years. We provide correlative evidence to support the potential contribution of adalimumab, a TNFα inhibitor, to the development of iTTP. We offer several educational insights regarding the identification of atypical presentations of iTTP owing to the longstanding disease course and numerous clinical comorbidities seen in this patient. |
| first_indexed | 2024-12-20T21:39:37Z |
| format | Article |
| id | doaj.art-d2b42c09d15f4379bcf46e961c1ce451 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-12-20T21:39:37Z |
| publishDate | 2021-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-d2b42c09d15f4379bcf46e961c1ce4512022-12-21T19:25:51ZengWileyClinical Case Reports2050-09042021-10-01910n/an/a10.1002/ccr3.4850A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic strokeMark E. Pepin0Eyad Saca1Soo Y. Kwon2Jori May3Department of Biomedical Engineering University of Alabama at Birmingham Birmingham AL USADepartment of Neurology University of Alabama at Birmingham Birmingham AL USADepartment of Neurology University of Alabama at Birmingham Birmingham AL USADepartment of Medicine Division of Hematology/Oncology University of Alabama at Birmingham Birmingham AL USAAbstract Prompt recognition and treatment for thrombotic thrombocytopenic purpura (TTP) are critical to prevent the irreversible manifestations of this rare and quickly fatal hematologic disorder. Untreated TTP is typically a rapid‐onset disease with mortality exceeding 90% within days in the absence of appropriate treatment. In the current report, we describe a case of immune‐mediated TTP (iTTP) in a 62‐year‐old man manifesting as longstanding thrombocytopenia, recurrent cardioembolic strokes, and valvular thrombogenesis over a period of 3 years. We provide correlative evidence to support the potential contribution of adalimumab, a TNFα inhibitor, to the development of iTTP. We offer several educational insights regarding the identification of atypical presentations of iTTP owing to the longstanding disease course and numerous clinical comorbidities seen in this patient.https://doi.org/10.1002/ccr3.4850adalimumabmicroangiopathythromboembolic strokethrombotic thrombocytopenic purpura |
| spellingShingle | Mark E. Pepin Eyad Saca Soo Y. Kwon Jori May A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke Clinical Case Reports adalimumab microangiopathy thromboembolic stroke thrombotic thrombocytopenic purpura |
| title | A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke |
| title_full | A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke |
| title_fullStr | A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke |
| title_full_unstemmed | A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke |
| title_short | A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke |
| title_sort | case of smoldering immune mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke |
| topic | adalimumab microangiopathy thromboembolic stroke thrombotic thrombocytopenic purpura |
| url | https://doi.org/10.1002/ccr3.4850 |
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