Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury
Traumatic brain injury (TBI) is a common and prevalent condition that affects large numbers of people across a range of ages. Individuals engaging in physical activities and victims of accidents are at a higher risk for TBI. There is a lack of available treatment specifically for TBI. Given the diff...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2020.00769/full |
| _version_ | 1818848094513528832 |
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| author | Caroline E. Black Eugene Zhou Caitlin M. DeAngelo Isaac Asante Stan G. Louie Stan G. Louie Nicos A. Petasis Nicos A. Petasis Nicos A. Petasis Mark S. Humayun Mark S. Humayun |
| author_facet | Caroline E. Black Eugene Zhou Caitlin M. DeAngelo Isaac Asante Stan G. Louie Stan G. Louie Nicos A. Petasis Nicos A. Petasis Nicos A. Petasis Mark S. Humayun Mark S. Humayun |
| author_sort | Caroline E. Black |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) is a common and prevalent condition that affects large numbers of people across a range of ages. Individuals engaging in physical activities and victims of accidents are at a higher risk for TBI. There is a lack of available treatment specifically for TBI. Given the difficulty to determine its precise location in the brain, TBI remains difficult to fully diagnose or treat. Herein, we disclose a novel strategy for directing therapeutic agents to TBI sites, without the need to determine the precise location of the TBI activity in the brain. This novel approach is based on the use of a cyanine dye nanocage carrying Gabapentin, a known TBI therapeutic agent. Upon exposure of the cyanine nanocage to near-infrared light, the local release of Gabapentin is triggered, selectively at the TBI-affected site. |
| first_indexed | 2024-12-19T06:11:53Z |
| format | Article |
| id | doaj.art-d2b469f598d74b4b820fdff5ac2e92d4 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-19T06:11:53Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-d2b469f598d74b4b820fdff5ac2e92d42022-12-21T20:33:00ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462020-08-01810.3389/fchem.2020.00769563950Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain InjuryCaroline E. Black0Eugene Zhou1Caitlin M. DeAngelo2Isaac Asante3Stan G. Louie4Stan G. Louie5Nicos A. Petasis6Nicos A. Petasis7Nicos A. Petasis8Mark S. Humayun9Mark S. Humayun10Department of Chemistry, University of Southern California, Los Angeles, CA, United StatesSchool of Pharmacy, University of Southern California, Los Angeles, CA, United StatesDepartment of Chemistry, University of Southern California, Los Angeles, CA, United StatesSchool of Pharmacy, University of Southern California, Los Angeles, CA, United StatesSchool of Pharmacy, University of Southern California, Los Angeles, CA, United StatesGinsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, United StatesDepartment of Chemistry, University of Southern California, Los Angeles, CA, United StatesSchool of Pharmacy, University of Southern California, Los Angeles, CA, United StatesGinsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, United StatesGinsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, United StatesKeck School of Medicine, Viterbi School of Engineering, and Roski Eye Institute, University of Southern California, Los Angeles, CA, United StatesTraumatic brain injury (TBI) is a common and prevalent condition that affects large numbers of people across a range of ages. Individuals engaging in physical activities and victims of accidents are at a higher risk for TBI. There is a lack of available treatment specifically for TBI. Given the difficulty to determine its precise location in the brain, TBI remains difficult to fully diagnose or treat. Herein, we disclose a novel strategy for directing therapeutic agents to TBI sites, without the need to determine the precise location of the TBI activity in the brain. This novel approach is based on the use of a cyanine dye nanocage carrying Gabapentin, a known TBI therapeutic agent. Upon exposure of the cyanine nanocage to near-infrared light, the local release of Gabapentin is triggered, selectively at the TBI-affected site.https://www.frontiersin.org/article/10.3389/fchem.2020.00769/fullcyanine dyenear-infraredlight-activatedtraumatic brain injury (TBI)gabapentin |
| spellingShingle | Caroline E. Black Eugene Zhou Caitlin M. DeAngelo Isaac Asante Stan G. Louie Stan G. Louie Nicos A. Petasis Nicos A. Petasis Nicos A. Petasis Mark S. Humayun Mark S. Humayun Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury Frontiers in Chemistry cyanine dye near-infrared light-activated traumatic brain injury (TBI) gabapentin |
| title | Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury |
| title_full | Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury |
| title_fullStr | Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury |
| title_full_unstemmed | Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury |
| title_short | Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury |
| title_sort | cyanine nanocages activated by near infrared light for the targeted treatment of traumatic brain injury |
| topic | cyanine dye near-infrared light-activated traumatic brain injury (TBI) gabapentin |
| url | https://www.frontiersin.org/article/10.3389/fchem.2020.00769/full |
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