Evaluation of Dysfunctional HDL by Myeloperoxidase/Paraoxonase Ratio in Unexplained Infertility Patients Undergoing IVF/ICSI
The relationship between oxidative stress and unexplained infertility (UEI) has not been studied in detail. This is the first study to evaluate dysfunctional high-density lipoprotein (HDL) by the myeloperoxidase (MPO) and paraoxonase (PON) ratio to investigate the role of oxidative stress in UEI. Ma...
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1506 |
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| author | Kadriye Erdoğan Nazli Tunca Sanlier Emine Utlu Özen Süleyman Erol Inci Kahyaoğlu Salim Neselioglu Özcan Erel Serra Akar Yaprak Engin Üstün |
| author_facet | Kadriye Erdoğan Nazli Tunca Sanlier Emine Utlu Özen Süleyman Erol Inci Kahyaoğlu Salim Neselioglu Özcan Erel Serra Akar Yaprak Engin Üstün |
| author_sort | Kadriye Erdoğan |
| collection | DOAJ |
| description | The relationship between oxidative stress and unexplained infertility (UEI) has not been studied in detail. This is the first study to evaluate dysfunctional high-density lipoprotein (HDL) by the myeloperoxidase (MPO) and paraoxonase (PON) ratio to investigate the role of oxidative stress in UEI. Materials and Methods: Patients with UEI (study group, <i>n</i> = 40) and male factor infertility (control group, <i>n</i> = 36) were included in this prospective study. Demographics and laboratory assessments were analyzed. Results: Total dosages of gonadotropin were higher in UEI when compared to the control group (<i>p</i> = 0.033). Number of Grade 1 embryos and the quality of blastocysts were lower in UEI than in the control group (<i>p</i> = 0.024, <i>p</i> = 0.020, respectively), whereas serum MPO/PON ratio was higher in UEI (<i>p</i> = 0.042). Stepwise linear regression analysis revealed that serum MPO/PON ratio levels could significantly predict the duration of infertility (<i>p</i> = 0.012). Conclusions: Serum MPO/PON ratio increased in patients with UEI, whereas the number of Grade 1 embryos and the quality of blastocysts decreased. Similar clinical pregnacy rates were found in both groups but the ET on day five is associated with higher clinical pregnancy rate in the male factor infertility. |
| first_indexed | 2024-03-11T08:38:04Z |
| format | Article |
| id | doaj.art-d2b5c933eaa04037ade4cf41181cb95e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:38:04Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-d2b5c933eaa04037ade4cf41181cb95e2023-11-16T21:20:31ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124150610.3390/jcm12041506Evaluation of Dysfunctional HDL by Myeloperoxidase/Paraoxonase Ratio in Unexplained Infertility Patients Undergoing IVF/ICSIKadriye Erdoğan0Nazli Tunca Sanlier1Emine Utlu Özen2Süleyman Erol3Inci Kahyaoğlu4Salim Neselioglu5Özcan Erel6Serra Akar7Yaprak Engin Üstün8Department of Obstetrics and Gynecology, Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Health Sciences University, 06830 Ankara, TurkeyDepartment of Obstetrics and Gynecology, Ankara City Hospital, 06800 Ankara, TurkeyDepartment of Obstetrics and Gynecology, Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Health Sciences University, 06830 Ankara, TurkeyDepartment of Obstetrics and Gynecology, Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Health Sciences University, 06830 Ankara, TurkeyDepartment of Obstetrics and Gynecology, Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Health Sciences University, 06830 Ankara, TurkeyDepartment of Obstetrics and Gynecology, Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Health Sciences University, 06830 Ankara, TurkeyDepartment of Obstetrics and Gynecology, Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Health Sciences University, 06830 Ankara, TurkeyDepartment of Obstetrics and Gynecology, Ankara City Hospital, 06800 Ankara, TurkeyDepartment of Obstetrics and Gynecology, Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Health Sciences University, 06830 Ankara, TurkeyThe relationship between oxidative stress and unexplained infertility (UEI) has not been studied in detail. This is the first study to evaluate dysfunctional high-density lipoprotein (HDL) by the myeloperoxidase (MPO) and paraoxonase (PON) ratio to investigate the role of oxidative stress in UEI. Materials and Methods: Patients with UEI (study group, <i>n</i> = 40) and male factor infertility (control group, <i>n</i> = 36) were included in this prospective study. Demographics and laboratory assessments were analyzed. Results: Total dosages of gonadotropin were higher in UEI when compared to the control group (<i>p</i> = 0.033). Number of Grade 1 embryos and the quality of blastocysts were lower in UEI than in the control group (<i>p</i> = 0.024, <i>p</i> = 0.020, respectively), whereas serum MPO/PON ratio was higher in UEI (<i>p</i> = 0.042). Stepwise linear regression analysis revealed that serum MPO/PON ratio levels could significantly predict the duration of infertility (<i>p</i> = 0.012). Conclusions: Serum MPO/PON ratio increased in patients with UEI, whereas the number of Grade 1 embryos and the quality of blastocysts decreased. Similar clinical pregnacy rates were found in both groups but the ET on day five is associated with higher clinical pregnancy rate in the male factor infertility.https://www.mdpi.com/2077-0383/12/4/1506unexplained infertilitydysfunctional high-density lipoproteinmyeloperoxidaseparaoxonase |
| spellingShingle | Kadriye Erdoğan Nazli Tunca Sanlier Emine Utlu Özen Süleyman Erol Inci Kahyaoğlu Salim Neselioglu Özcan Erel Serra Akar Yaprak Engin Üstün Evaluation of Dysfunctional HDL by Myeloperoxidase/Paraoxonase Ratio in Unexplained Infertility Patients Undergoing IVF/ICSI Journal of Clinical Medicine unexplained infertility dysfunctional high-density lipoprotein myeloperoxidase paraoxonase |
| title | Evaluation of Dysfunctional HDL by Myeloperoxidase/Paraoxonase Ratio in Unexplained Infertility Patients Undergoing IVF/ICSI |
| title_full | Evaluation of Dysfunctional HDL by Myeloperoxidase/Paraoxonase Ratio in Unexplained Infertility Patients Undergoing IVF/ICSI |
| title_fullStr | Evaluation of Dysfunctional HDL by Myeloperoxidase/Paraoxonase Ratio in Unexplained Infertility Patients Undergoing IVF/ICSI |
| title_full_unstemmed | Evaluation of Dysfunctional HDL by Myeloperoxidase/Paraoxonase Ratio in Unexplained Infertility Patients Undergoing IVF/ICSI |
| title_short | Evaluation of Dysfunctional HDL by Myeloperoxidase/Paraoxonase Ratio in Unexplained Infertility Patients Undergoing IVF/ICSI |
| title_sort | evaluation of dysfunctional hdl by myeloperoxidase paraoxonase ratio in unexplained infertility patients undergoing ivf icsi |
| topic | unexplained infertility dysfunctional high-density lipoprotein myeloperoxidase paraoxonase |
| url | https://www.mdpi.com/2077-0383/12/4/1506 |
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