IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration

IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration

Unlike the current injectable influenza vaccines, intranasally administered influenza vaccines induce influenza virus-specific IgA antibodies in the local respiratory mucosa as well as IgG antibodies in the systemic circulation. Our previous study showed that after five volunteers underwent intranas...

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Bibliographic Details
Main Authors: Yoshihiko Terauchi, Kaori Sano, Akira Ainai, Shinji Saito, Yuki Taga, Kiyoko Ogawa-Goto, Shin-ichi Tamura, Takato Odagiri, Masato Tashiro, Mikiya Fujieda, Tadaki Suzuki, Hideki Hasegawa
Format: Article
Language:English
Published: Taylor & Francis Group 2018-06-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
secretory iga antibody
multimeric siga antibody
influenza virus
intranasal inactivated influenza vaccine
upper respiratory mucosa
Online Access:http://dx.doi.org/10.1080/21645515.2018.1438791

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