Short- and Midterm Comparison of Platelet-Rich Plasma with Hyaluronic Acid versus Leucocyte and Platelet-Rich Plasma on Pain and Function to Treat Hip Osteoarthritis. A Retrospective Study
Hip osteoarthritis (HOA) leads to pain and reduced function. The use of intra-articular injections based on corticosteroids, platelet-rich plasma (PRP), or hyaluronic acid (HA) is becoming a common symptomatic therapy for HOA. For the first time, we compare the effectiveness of plasma with a high co...
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MDPI AG
2021-11-01
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| Online Access: | https://www.mdpi.com/2310-2861/7/4/222 |
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| author | Michelangelo Palco Paolo Rizzo Giorgio Carmelo Basile Angelo Alito Daniele Bruschetta Maria Accorinti Roberto Restuccia Danilo Leonetti |
| author_facet | Michelangelo Palco Paolo Rizzo Giorgio Carmelo Basile Angelo Alito Daniele Bruschetta Maria Accorinti Roberto Restuccia Danilo Leonetti |
| author_sort | Michelangelo Palco |
| collection | DOAJ |
| description | Hip osteoarthritis (HOA) leads to pain and reduced function. The use of intra-articular injections based on corticosteroids, platelet-rich plasma (PRP), or hyaluronic acid (HA) is becoming a common symptomatic therapy for HOA. For the first time, we compare the effectiveness of plasma with a high concentration of platelets and leukocytes (L-PRP) with PRP+HA in patients with mild to moderate HOA. A total of 26 patients in each group were administered with either L-PRP or PRP+HA. Outcomes were evaluated at baseline, 3 months, and 1 year after the injection. The mean visual analog scale (VAS) and Harris hip score (HHS) within and between groups among different time points were compared using repeated measures ANCOVA (age set as a covariate). Both treatments were effective in reducing VAS, but not in significantly increasing HHS. In the group treated with L-PRP, VAS showed interaction between time and treatment (in favor of L-PRP). Pairwise comparison for treatment and time point evidenced a significant difference at 1-year follow-up between L-PRP and PRP-HA. Outcomes support the idea that both treatments may be effective in reducing pain, with maximal pain reduction achieved after 3 months. L-PRP showed better results in reducing VAS over time. Both treatments are effective at reducing pain in the short to medium term. L-PRP could be the treatment of choice due to a more marked effect over time. Nevertheless, further research is needed to better describe the clinical outcome of these formulations. |
| first_indexed | 2024-03-10T04:03:43Z |
| format | Article |
| id | doaj.art-d2b9d85f06f04227867f8977ff1f8ea2 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-10T04:03:43Z |
| publishDate | 2021-11-01 |
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| spelling | doaj.art-d2b9d85f06f04227867f8977ff1f8ea22023-11-23T08:28:11ZengMDPI AGGels2310-28612021-11-017422210.3390/gels7040222Short- and Midterm Comparison of Platelet-Rich Plasma with Hyaluronic Acid versus Leucocyte and Platelet-Rich Plasma on Pain and Function to Treat Hip Osteoarthritis. A Retrospective StudyMichelangelo Palco0Paolo Rizzo1Giorgio Carmelo Basile2Angelo Alito3Daniele Bruschetta4Maria Accorinti5Roberto Restuccia6Danilo Leonetti7Department of Biomedical, Dental and Morphological and Functional Images, Section of Orthopedics and Traumatology, University of Messina, 98122 Messina, ItalyDepartment of Biomedical, Dental and Morphological and Functional Images, Section of Orthopedics and Traumatology, University of Messina, 98122 Messina, ItalyDepartment of Biomedical, Dental and Morphological and Functional Images, University of Messina, 98122 Messina, ItalyComplex Operating Unit of Physical and Rehabilitation Medicine and Sports Medicine, Policlinico Universitario G. Martino, 98124 Messina, ItalyDepartment of Biomedical, Dental and Morphological and Functional Images, University of Messina, 98122 Messina, ItalyComplex Operating Unit of Physical and Rehabilitation Medicine and Sports Medicine, Policlinico Universitario G. Martino, 98124 Messina, ItalyComplex Operating Unit of Physical and Rehabilitation Medicine and Sports Medicine, Policlinico Universitario G. Martino, 98124 Messina, ItalyDepartment of Biomedical, Dental and Morphological and Functional Images, Section of Orthopedics and Traumatology, University of Messina, 98122 Messina, ItalyHip osteoarthritis (HOA) leads to pain and reduced function. The use of intra-articular injections based on corticosteroids, platelet-rich plasma (PRP), or hyaluronic acid (HA) is becoming a common symptomatic therapy for HOA. For the first time, we compare the effectiveness of plasma with a high concentration of platelets and leukocytes (L-PRP) with PRP+HA in patients with mild to moderate HOA. A total of 26 patients in each group were administered with either L-PRP or PRP+HA. Outcomes were evaluated at baseline, 3 months, and 1 year after the injection. The mean visual analog scale (VAS) and Harris hip score (HHS) within and between groups among different time points were compared using repeated measures ANCOVA (age set as a covariate). Both treatments were effective in reducing VAS, but not in significantly increasing HHS. In the group treated with L-PRP, VAS showed interaction between time and treatment (in favor of L-PRP). Pairwise comparison for treatment and time point evidenced a significant difference at 1-year follow-up between L-PRP and PRP-HA. Outcomes support the idea that both treatments may be effective in reducing pain, with maximal pain reduction achieved after 3 months. L-PRP showed better results in reducing VAS over time. Both treatments are effective at reducing pain in the short to medium term. L-PRP could be the treatment of choice due to a more marked effect over time. Nevertheless, further research is needed to better describe the clinical outcome of these formulations.https://www.mdpi.com/2310-2861/7/4/222PRPosteoarthritiscartilagedegenerationpaingel |
| spellingShingle | Michelangelo Palco Paolo Rizzo Giorgio Carmelo Basile Angelo Alito Daniele Bruschetta Maria Accorinti Roberto Restuccia Danilo Leonetti Short- and Midterm Comparison of Platelet-Rich Plasma with Hyaluronic Acid versus Leucocyte and Platelet-Rich Plasma on Pain and Function to Treat Hip Osteoarthritis. A Retrospective Study Gels PRP osteoarthritis cartilage degeneration pain gel |
| title | Short- and Midterm Comparison of Platelet-Rich Plasma with Hyaluronic Acid versus Leucocyte and Platelet-Rich Plasma on Pain and Function to Treat Hip Osteoarthritis. A Retrospective Study |
| title_full | Short- and Midterm Comparison of Platelet-Rich Plasma with Hyaluronic Acid versus Leucocyte and Platelet-Rich Plasma on Pain and Function to Treat Hip Osteoarthritis. A Retrospective Study |
| title_fullStr | Short- and Midterm Comparison of Platelet-Rich Plasma with Hyaluronic Acid versus Leucocyte and Platelet-Rich Plasma on Pain and Function to Treat Hip Osteoarthritis. A Retrospective Study |
| title_full_unstemmed | Short- and Midterm Comparison of Platelet-Rich Plasma with Hyaluronic Acid versus Leucocyte and Platelet-Rich Plasma on Pain and Function to Treat Hip Osteoarthritis. A Retrospective Study |
| title_short | Short- and Midterm Comparison of Platelet-Rich Plasma with Hyaluronic Acid versus Leucocyte and Platelet-Rich Plasma on Pain and Function to Treat Hip Osteoarthritis. A Retrospective Study |
| title_sort | short and midterm comparison of platelet rich plasma with hyaluronic acid versus leucocyte and platelet rich plasma on pain and function to treat hip osteoarthritis a retrospective study |
| topic | PRP osteoarthritis cartilage degeneration pain gel |
| url | https://www.mdpi.com/2310-2861/7/4/222 |
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