Negative Feedback Role of Astrocytes in Shaping Excitation in Brain Cell Co-cultures

Negative Feedback Role of Astrocytes in Shaping Excitation in Brain Cell Co-cultures

Glial cells play an important role in maintaining neuronal homeostasis and may thus influence excitability in epileptogenesis. These cells in the brain have glutamate (Glu) transporters, which remove this neurotransmitter from the extracellular space. Lack of negative (−) feedback makes local neuron...

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Bibliographic Details
Main Authors: Elnaz Khezerlou, Neela Prajapati, Mark A. DeCoster
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
astrocyte
calcium imaging
glutamate
excitotoxicity
neurons
blood brain barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.651509/full

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