Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis
Retinal oxidative stress is a common secondary feature of many retinal diseases. Though it may not be the initial insult, it is a major contributor to the pathogenesis of highly prevalent retinal dystrophic diseases like macular degeneration, diabetic retinopathy, and retinitis pigmentosa. We explor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/10/1595 |
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| author | Larissa Ikelle Muna I. Naash Muayyad R. Al-Ubaidi |
| author_facet | Larissa Ikelle Muna I. Naash Muayyad R. Al-Ubaidi |
| author_sort | Larissa Ikelle |
| collection | DOAJ |
| description | Retinal oxidative stress is a common secondary feature of many retinal diseases. Though it may not be the initial insult, it is a major contributor to the pathogenesis of highly prevalent retinal dystrophic diseases like macular degeneration, diabetic retinopathy, and retinitis pigmentosa. We explored the role of superoxide dismutase 3 (SOD3) in retinal homeostasis since SOD3 protects the extracellular matrix (ECM) from oxidative injury. We show that SOD3 is mainly extracellularly localized and is upregulated as a result of environmental and pathogenic stress. Ablation of SOD3 resulted in reduced functional electroretinographic responses and number of photoreceptors, which is exacerbated with age. By contrast, overexpression showed increased electroretinographic responses and increased number of photoreceptors at young ages, but appears deleterious as the animal ages, as determined from the associated functional decline. Our exploration shows that SOD3 is vital to retinal homeostasis but its levels are tightly regulated. This suggests that SOD3 augmentation to combat oxidative stress during retinal degenerative changes may only be effective in the short-term. |
| first_indexed | 2024-03-10T06:45:43Z |
| format | Article |
| id | doaj.art-d2ba27faeb0b4987ab82e61cb4eca46e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T06:45:43Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-d2ba27faeb0b4987ab82e61cb4eca46e2023-11-22T17:16:25ZengMDPI AGAntioxidants2076-39212021-10-011010159510.3390/antiox10101595Modulation of SOD3 Levels Is Detrimental to Retinal HomeostasisLarissa Ikelle0Muna I. Naash1Muayyad R. Al-Ubaidi2Department of Biomedical Engineering, University of Houston, Houston, TX 77004, USADepartment of Biomedical Engineering, University of Houston, Houston, TX 77004, USADepartment of Biomedical Engineering, University of Houston, Houston, TX 77004, USARetinal oxidative stress is a common secondary feature of many retinal diseases. Though it may not be the initial insult, it is a major contributor to the pathogenesis of highly prevalent retinal dystrophic diseases like macular degeneration, diabetic retinopathy, and retinitis pigmentosa. We explored the role of superoxide dismutase 3 (SOD3) in retinal homeostasis since SOD3 protects the extracellular matrix (ECM) from oxidative injury. We show that SOD3 is mainly extracellularly localized and is upregulated as a result of environmental and pathogenic stress. Ablation of SOD3 resulted in reduced functional electroretinographic responses and number of photoreceptors, which is exacerbated with age. By contrast, overexpression showed increased electroretinographic responses and increased number of photoreceptors at young ages, but appears deleterious as the animal ages, as determined from the associated functional decline. Our exploration shows that SOD3 is vital to retinal homeostasis but its levels are tightly regulated. This suggests that SOD3 augmentation to combat oxidative stress during retinal degenerative changes may only be effective in the short-term.https://www.mdpi.com/2076-3921/10/10/1595retinaextracellular matrixoxidative stressSOD3retinal degenerationsuperoxide dismutase 3 |
| spellingShingle | Larissa Ikelle Muna I. Naash Muayyad R. Al-Ubaidi Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis Antioxidants retina extracellular matrix oxidative stress SOD3 retinal degeneration superoxide dismutase 3 |
| title | Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis |
| title_full | Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis |
| title_fullStr | Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis |
| title_full_unstemmed | Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis |
| title_short | Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis |
| title_sort | modulation of sod3 levels is detrimental to retinal homeostasis |
| topic | retina extracellular matrix oxidative stress SOD3 retinal degeneration superoxide dismutase 3 |
| url | https://www.mdpi.com/2076-3921/10/10/1595 |
| work_keys_str_mv | AT larissaikelle modulationofsod3levelsisdetrimentaltoretinalhomeostasis AT munainaash modulationofsod3levelsisdetrimentaltoretinalhomeostasis AT muayyadralubaidi modulationofsod3levelsisdetrimentaltoretinalhomeostasis |