Effect of gynecological cancer and its treatment on bone mineral density and the risk of osteoporosis and osteoporotic fracture
Objective The purpose of this study was to evaluate the risk of osteopenia and osteoporosis by examining the bone mineral density (BMD) of the lumbar spine and femur in patients with gynecological cancer without bone metastasis and to evaluate the impact of treatment for different cancers on BMD. Me...
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| Format: | Article |
| Language: | English |
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Korean Society of Obstetrics and Gynecology
2020-07-01
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| Series: | Obstetrics & Gynecology Science |
| Subjects: | |
| Online Access: | http://www.ogscience.org/upload/pdf/ogs-20012.pdf |
| _version_ | 1819159871371608064 |
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| author | Jeong Eun Lee Che Yon Park Eunhyun Lee Yong Il Ji |
| author_facet | Jeong Eun Lee Che Yon Park Eunhyun Lee Yong Il Ji |
| author_sort | Jeong Eun Lee |
| collection | DOAJ |
| description | Objective The purpose of this study was to evaluate the risk of osteopenia and osteoporosis by examining the bone mineral density (BMD) of the lumbar spine and femur in patients with gynecological cancer without bone metastasis and to evaluate the impact of treatment for different cancers on BMD. Methods This study retrospectively reviewed the medical records of 243 women with gynecological cancer and 240 controls between March 2010 and December 2016. Patients with cervical cancer (n=105), endometrial cancer (n=63), and ovarian cancer (n=75) were treated with total hysterectomy including bilateral salpingo-oophorectomy and/or chemotherapy and/or radiotherapy. For the control group, healthy post-menopausal women without gynecologic cancer were selected. Results Before anticancer treatment, the BMD of patients with cervical cancer and ovarian cancer was significantly lower than that of the controls, and the BMD of patients with endometrial cancer was not significantly different from that of the controls. However, the BMD of endometrial cancer significantly decreased after treatment. According to the treatment methods, there were significant differences in the BMD of L3, L4, and the femur neck. Changes in the BMD were lowest in patients who underwent surgical treatment only, and the highest bone loss was found in patients who underwent postoperative concurrent chemoradiotherapy. Conclusion Patients with cervical and ovarian cancer had lower BMD than those in the control group before treatment, and patients with endometrial cancer had decreased bone density after treatment. Therefore, during the treatment of gynecological cancer, strategies should be implemented to mitigate these risks. |
| first_indexed | 2024-12-22T16:47:26Z |
| format | Article |
| id | doaj.art-d2bc044967ad442b8e0760d4d3472d5f |
| institution | Directory Open Access Journal |
| issn | 2287-8572 2287-8580 |
| language | English |
| last_indexed | 2024-12-22T16:47:26Z |
| publishDate | 2020-07-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj.art-d2bc044967ad442b8e0760d4d3472d5f2022-12-21T18:19:42ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802020-07-0163447047910.5468/ogs.200128550Effect of gynecological cancer and its treatment on bone mineral density and the risk of osteoporosis and osteoporotic fractureJeong Eun Lee0Che Yon Park1Eunhyun Lee2Yong Il JiDepartment of Obstetrics and Gynecology, Inje University, Haeundae Paik Hospital, Busan, KoreaDepartment of Obstetrics and Gynecology, Inje University, Haeundae Paik Hospital, Busan, KoreaDepartment of Obstetrics and Gynecology, Inje University, Haeundae Paik Hospital, Busan, KoreaObjective The purpose of this study was to evaluate the risk of osteopenia and osteoporosis by examining the bone mineral density (BMD) of the lumbar spine and femur in patients with gynecological cancer without bone metastasis and to evaluate the impact of treatment for different cancers on BMD. Methods This study retrospectively reviewed the medical records of 243 women with gynecological cancer and 240 controls between March 2010 and December 2016. Patients with cervical cancer (n=105), endometrial cancer (n=63), and ovarian cancer (n=75) were treated with total hysterectomy including bilateral salpingo-oophorectomy and/or chemotherapy and/or radiotherapy. For the control group, healthy post-menopausal women without gynecologic cancer were selected. Results Before anticancer treatment, the BMD of patients with cervical cancer and ovarian cancer was significantly lower than that of the controls, and the BMD of patients with endometrial cancer was not significantly different from that of the controls. However, the BMD of endometrial cancer significantly decreased after treatment. According to the treatment methods, there were significant differences in the BMD of L3, L4, and the femur neck. Changes in the BMD were lowest in patients who underwent surgical treatment only, and the highest bone loss was found in patients who underwent postoperative concurrent chemoradiotherapy. Conclusion Patients with cervical and ovarian cancer had lower BMD than those in the control group before treatment, and patients with endometrial cancer had decreased bone density after treatment. Therefore, during the treatment of gynecological cancer, strategies should be implemented to mitigate these risks.http://www.ogscience.org/upload/pdf/ogs-20012.pdfbone densitytreatment-associated cancerosteoporosis |
| spellingShingle | Jeong Eun Lee Che Yon Park Eunhyun Lee Yong Il Ji Effect of gynecological cancer and its treatment on bone mineral density and the risk of osteoporosis and osteoporotic fracture Obstetrics & Gynecology Science bone density treatment-associated cancer osteoporosis |
| title | Effect of gynecological cancer and its treatment on bone mineral density and the risk of osteoporosis and osteoporotic fracture |
| title_full | Effect of gynecological cancer and its treatment on bone mineral density and the risk of osteoporosis and osteoporotic fracture |
| title_fullStr | Effect of gynecological cancer and its treatment on bone mineral density and the risk of osteoporosis and osteoporotic fracture |
| title_full_unstemmed | Effect of gynecological cancer and its treatment on bone mineral density and the risk of osteoporosis and osteoporotic fracture |
| title_short | Effect of gynecological cancer and its treatment on bone mineral density and the risk of osteoporosis and osteoporotic fracture |
| title_sort | effect of gynecological cancer and its treatment on bone mineral density and the risk of osteoporosis and osteoporotic fracture |
| topic | bone density treatment-associated cancer osteoporosis |
| url | http://www.ogscience.org/upload/pdf/ogs-20012.pdf |
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