Amyotrophic Lateral Sclerosis Mechanism: Insights from the <i>Caenorhabditis elegans</i> Models

Amyotrophic Lateral Sclerosis Mechanism: Insights from the <i>Caenorhabditis elegans</i> Models

Amyotrophic Lateral Sclerosis (ALS) is a debilitating neurodegenerative condition characterized by the progressive degeneration of motor neurons. Despite extensive research in various model animals, the cellular signal mechanisms of ALS remain elusive, impeding the development of efficacious treatme...

Full description

Bibliographic Details
Main Authors:	Lili Chen, Shumei Zhang, Sai Liu, Shangbang Gao
Format:	Article
Language:	English
Published:	MDPI AG 2024-01-01
Series:	Cells
Subjects:	ALS <i>C. elegans</i> model cellular mechanism therapeutic application
Online Access:	https://www.mdpi.com/2073-4409/13/1/99

Similar Items

Disrupted autophagy and neuronal dysfunction in C. elegans knockin models of FUS amyotrophic lateral sclerosis
by: Saba N. Baskoylu, et al.
Published: (2022-01-01)

Microfluidic Device for Microinjection of <i>Caenorhabditis elegans</i>
by: Reza Ghaemi, et al.
Published: (2020-03-01)

Using a <i>Caenorhabditis elegans</i> Parkinson’s Disease Model to Assess Disease Progression and Therapy Efficiency
by: Samantha Hughes, et al.
Published: (2022-04-01)

Spaceflight Induces Strength Decline in <i>Caenorhabditis elegans</i>
by: Purushottam Soni, et al.
Published: (2023-10-01)

Astaxanthin Induces Transcriptomic Responses Associated with Lifespan Extension in <i>Caenorhabditis elegans</i>
by: Feng Ding, et al.
Published: (2022-10-01)

Biomonitoring of Indoor Air Fungal or Chemical Toxins with <i>Caenorhabditis elegans</i> nematodes
by: Sari Paavanen-Huhtala, et al.
Published: (2023-01-01)

Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans
by: Martine eTherrien, et al.
Published: (2014-04-01)

<i>Planococcus maritimu</i> ML1206 Strain Enhances Stress Resistance and Extends the Lifespan in <i>Caenorhabditis elegans</i> via FOXO/DAF-16
by: Jing-Shan Wu, et al.
Published: (2022-12-01)

Modeling Alzheimer’s Disease in <i>Caenorhabditis elegans</i>
by: Javier Alvarez, et al.
Published: (2022-01-01)

Stress Buffering and Longevity Effects of Amber Extract on <i>Caenorhabditis elegans</i> (<i>C. elegans</i>)
by: Sandra Somuah-Asante, et al.
Published: (2022-06-01)

BAM15 Relieves Neurodegeneration in Aged <i>Caenorhabditis elegans</i> and Extends Lifespan
by: Injeong Cho, et al.
Published: (2022-11-01)

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in <i>Caenorhabditis elegans</i>
by: Jing Wang, et al.
Published: (2020-01-01)

A Role for <i>Caenorhabditis elegans</i> COMPASS in Germline Chromatin Organization
by: Marion Herbette, et al.
Published: (2020-09-01)

Genetic Variation in <i>Caenorhabditis elegans</i> Responses to Pathogenic Microbiota
by: Yuqing Huang, et al.
Published: (2020-04-01)

Curcumin Acetylsalicylate Extends the Lifespan of <i>Caenorhabditis elegans</i>
by: Lei Zhou, et al.
Published: (2021-10-01)

Reducing Results Variance in Lifespan Machines: An Analysis of the Influence of Vibrotaxis on Wild-Type <i>Caenorhabditis elegans</i> for the Death Criterion
by: Joan Carles Puchalt, et al.
Published: (2020-10-01)

Modelling amyotrophic lateral sclerosis: progress and possibilities
by: Philip Van Damme, et al.
Published: (2017-05-01)

Molecular Basis of Neuronal Autophagy in Ageing: Insights from <i>Caenorhabditis elegans</i>
by: Georgios Konstantinidis, et al.
Published: (2021-03-01)

<i>Caenorhabditis elegans</i> as a Model to Study Manganese-Induced Neurotoxicity
by: Airton C. Martins, et al.
Published: (2022-09-01)

A Connectome-Based Digital Twin <i>Caenorhabditis elegans</i> Capable of Intelligent Sensorimotor Behavior
by: Zhongyu Chen, et al.
Published: (2023-05-01)

Impact of Molecular Weight Variations in <i>Dendrobium officinale</i> Polysaccharides on Antioxidant Activity and Anti-Obesity in <i>Caenorhabditis elegans</i>
by: Xiao Pang, et al.
Published: (2024-03-01)

Transcriptome Analysis of the Nematodes <i>Caenorhabditis elegans</i> and <i>Litoditis marina</i> in Different Food Environments
by: Peiqi Sun, et al.
Published: (2022-04-01)

Spermiogenesis in <i>Caenorhabditis elegans</i>: An Excellent Model to Explore the Molecular Basis for Sperm Activation
by: Yoshihiro Shimada, et al.
Published: (2023-04-01)

In Vitro Probiotic Properties and In Vivo Anti-Ageing Effects of <i>Lactoplantibacillus plantarum</i> PFA2018AU Strain Isolated from Carrots on <i>Caenorhabditis elegans</i>
by: Laura Pompa, et al.
Published: (2023-04-01)

Parallel-Channel Electrotaxis and Neuron Screening of <em>Caenorhabditis elegans</em>
by: Khaled Youssef, et al.
Published: (2020-08-01)

Association of <i>Euterpe oleracea</i>, <i>Bixa orellana</i>, <i>Myciaria dubia</i>, and <i>Astrocaryum aculeatum</i> (the Terasen<sup>®</sup> Nutraceutical) Increases the Lifespan of <i>Caenorhabditis elegans</i>
by: Ester Lopes de Melo, et al.
Published: (2023-11-01)

Antitumoral Drug Potential of Tryptophan-Betaxanthin and Related Plant Betalains in the <i>Caenorhabditis elegans</i> Tumoral Model
by: Paula Henarejos-Escudero, et al.
Published: (2020-07-01)

Enhanced Uptake of Arsenic Induces Increased Toxicity with Cadmium at Non-Toxic Concentrations on <i>Caenorhabditis elegans</i>
by: Chengcheng Pei, et al.
Published: (2022-03-01)

Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i>
by: Julia Tortajada-Pérez, et al.
Published: (2025-01-01)

Effects of NAD<sup>+</sup> in <i>Caenorhabditis elegans</i> Models of Neuronal Damage
by: Yuri Lee, et al.
Published: (2020-07-01)

Flowers of <i>Allium cepa</i> L. as Nutraceuticals: Phenolic Composition and Anti-Obesity and Antioxidant Effects in <i>Caenorhabditis elegans</i>
by: Cristina Moliner, et al.
Published: (2023-03-01)

<i>Caenorhabditis elegans</i> as a Model for the Effects of Phytochemicals on Mitochondria and Aging
by: Fabian Schmitt, et al.
Published: (2022-10-01)

Difference in Intestine Content of <i>Caenorhabditis elegans</i> When Fed on Non-Pathogenic or Pathogenic Bacteria
by: Farzad Rezaeianaran, et al.
Published: (2023-07-01)

<i>Caenorhabditis elegans</i> as an In Vivo Model for the Discovery and Development of Natural Plant-Based Antimicrobial Compounds
by: Samah H. O. Zarroug, et al.
Published: (2023-07-01)

Calumenin, a Ca<sup>2+</sup> Binding Protein, Is Required for Dauer Formation in <i>Caenorhabditis elegans</i>
by: Kyung Eun Lee, et al.
Published: (2023-03-01)

Antioxidant Characterization and Biological Effects of Grape Pomace Extracts Supplementation in <i>Caenorhabditis elegans</i>
by: Begoña Ayuda-Durán, et al.
Published: (2019-02-01)

A Novel In Vivo Method Using <i>Caenorhabditis elegans</i> to Evaluate α-Glucosidase Inhibition by Natural Products for Type 2 Diabetes Treatment
by: María Pilar de Torre, et al.
Published: (2024-12-01)

Oxidative Stress, Oxidative Damage, and Cell Apoptosis: Toxicity Induced by Arecoline in <i>Caenorhabditis elegans</i> and Screening of Mitigating Agents
by: Kaiping Xiang, et al.
Published: (2024-08-01)

The Endogenous Metabolite Glycerophosphocholine Promotes Longevity and Fitness in <i>Caenorhabditis elegans</i>
by: Jia-Yu Liu, et al.
Published: (2022-02-01)

Preparation of <i>Dendrobium officinale</i> Flower Anthocyanin and Extended Lifespan in <i>Caenorhabditis elegans</i>
by: Shuangxi Li, et al.
Published: (2022-12-01)